Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | VCP | P55072 | 5/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3848676 | 0.88 | HRH3 (0.55) | HRH3ROCK2CYP3A4VCPTLR9 | |
| SCHEMBL2952638 | 0.83 | HRH3 (0.67) | HRH3ROCK2CYP3A4VCP | |
| SCHEMBL5017056 | 0.82 | HRH3 (0.58) | HRH3 | |
| SCHEMBL2950114 | 0.77 | HRH3 (0.73) | HRH3ROCK2CYP3A4ALDH1A1 | |
| SCHEMBL2951205 | 0.75 | HRH3 (0.67) | HRH3ROCK2CYP3A4VCPTLR9 | |
| SCHEMBL2943709 | 0.74 | HRH3 (0.66) | HRH3ALDH1A1 | |
| SCHEMBL2952603 | 0.74 | HRH3 (0.83) | HRH3 | |
| SCHEMBL2947010 | 0.73 | HRH3 (0.82) | HRH3 | |
| SCHEMBL2949179 | 0.73 | HRH3 (0.78) | HRH3ROCK2CYP3A4 | |
| SCHEMBL2952637 | 0.73 | HRH3 (0.66) | HRH3ROCK2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841734-B1 | 5-AMINOINDOLE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2009-07-29 | — | — | EP | claimed |