Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 6/20 | 0.76 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 2/20 | 0.47 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL121454 | 0.89 | FGFR1 (0.76) | FGFR1THRBHPGD | |
| Hydrochloric Acid SCHEMBL7986276 | 0.85 | FGFR1 (0.97) | FGFR1HPGDSRC | |
| SCHEMBL12817507 | 0.84 | FGFR1 (0.84) | FGFR1THRBHPGDSRC | |
| SCHEMBL12822195 | 0.83 | FGFR1 (0.64) | FGFR1THRBHPGDSRC | |
| SCHEMBL12822193 | 0.82 | FGFR1 (0.71) | FGFR1THRBHPGDSRCATM | |
| SCHEMBL12822123 | 0.81 | FGFR1 (0.78) | FGFR1THRBHPGDSRC | |
| SCHEMBL13666321 | 0.81 | FGFR1 (0.51) | FGFR1THRBHPGDATMTP53 | |
| SCHEMBL12822329 | 0.80 | FGFR1 (0.67) | FGFR1THRBHPGDSRCATM | |
| SCHEMBL12821909 | 0.79 | FGFR1 (0.66) | FGFR1THRBHPGD | |
| SCHEMBL29987340 | 0.79 | FGFR1 (0.85) | FGFR1THRBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009119776-A1 | FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF | 武田薬品工業株式会社 (JP) | 2009-10-01 | — | — | WO | disclosed |
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |