Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | PER2 | O15055 | 1/20 | 0.34 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL798077 | 0.87 | POLB (0.55) | POLBMEN1KMT2AP2RX7ALDH1A1 | |
| SCHEMBL793587 | 0.83 | MEN1 (0.46) | POLBMEN1KMT2ALMNACYP3A4 | |
| SCHEMBL27918927 | 0.82 | POLB (0.56) | POLBMEN1KMT2AP2RX7ALDH1A1 | |
| SCHEMBL688493 | 0.82 | POLB (0.60) | POLBMEN1KMT2AP2RX7ALDH1A1 | |
| SCHEMBL3824098 | 0.77 | POLB (0.66) | POLBMEN1KMT2ATDP1P2RX7 | |
| SCHEMBL1077354 | 0.71 | TSHR (0.41) | MEN1KMT2ALMNACYP3A4CYP2C9 | |
| SCHEMBL1078957 | 0.71 | TSHR (0.41) | MEN1KMT2ALMNACYP3A4CYP2C9 | |
| SCHEMBL21133426 | 0.70 | POLB (0.48) | POLBP2RX7PER2CRY2PIK3CD | |
| SCHEMBL12145251 | 0.70 | POLB (0.68) | POLBMEN1KMT2ATDP1P2RX7 | |
| SCHEMBL31733928 | 0.69 | POLB (0.62) | POLBMEN1KMT2AP2RX7ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2028247-A1 | Use of 1-alkyl-5-oxo-pyrrolidine-3-carbolic acid esters as gas hydrate inhibitors with improved biological degradability | CLARIANT INTERNATIONAL LTD. (CH) | 2009-02-25 | — | — | EP | disclosed |