Trifluoroacetic Acid

Trifluoroacetic Acid

SCHEMBL3844974

CS(=O)(=O)c1cccc(N2CCN(c3ncnc4ccc(-c5c[nH]nc5-c5ccc(C#N)cc5)cc34)CC2)c1.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F

nearest known ligand 0.43

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 15/20 0.43
CYP1A2 P05177 14/20 0.43
ALDH1A1 P00352 10/20 0.43
CLK4 Q9HAZ1 10/20 0.43
HIF1A Q16665 7/20 0.43
MEN1 O00255 6/20 0.43
KMT2A Q03164 6/20 0.43
USP2 O75604 6/20 0.43
LMNA P02545 8/20 0.42
HPGD P15428 4/20 0.42
KDM4E B2RXH2 3/20 0.42
HSD17B10 Q99714 3/20 0.42
MAPT P10636 1/20 0.42
CYP2C19 P33261 7/20 0.41
MAPK1 P28482 6/20 0.41
TSHR P16473 5/20 0.41
CYP2D6 P10635 3/20 0.41
KIT P10721 2/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
GPR6 P46095 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL3848758 0.95 CYP3A4 (0.49) CYP3A4CYP1A2ALDH1A1CLK4HIF1A
Trifluoroacetic Acid SCHEMBL3852806 0.92 CYP3A4 (0.43) CYP3A4CYP1A2ALDH1A1CLK4HIF1A
Trifluoroacetic Acid SCHEMBL3854299 0.91 AKT1 (0.43) CYP3A4CYP1A2ALDH1A1CLK4HIF1A
Trifluoroacetic Acid SCHEMBL3847046 0.90 CYP3A4 (0.42) CYP3A4CYP1A2ALDH1A1CLK4HIF1A
Trifluoroacetic Acid SCHEMBL3845308 0.90 CYP3A4 (0.48) CYP3A4CYP1A2ALDH1A1CLK4HIF1A
Trifluoroacetic Acid SCHEMBL5852082 0.89 CYP3A4 (0.39) CYP3A4CYP1A2ALDH1A1CLK4HIF1A
Trifluoroacetic Acid SCHEMBL5853394 0.88 CYP3A4 (0.44) CYP3A4CYP1A2ALDH1A1CLK4HIF1A
Trifluoroacetic Acid SCHEMBL3852874 0.87 CYP3A4 (0.43) CYP3A4CYP1A2ALDH1A1CLK4HIF1A
Trifluoroacetic Acid SCHEMBL3851324 0.86 CYP3A4 (0.46) CYP3A4CYP1A2ALDH1A1CLK4HIF1A
SCHEMBL3848244 0.82 CYP1A2 (0.43) CYP3A4CYP1A2ALDH1A1CLK4HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2048142-A2 Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof Eisai R&D Management Co., Ltd. (JP) 2009-04-15 EP disclosed
US-7074801-B1 Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof EISAI CO., LTD. (JP) 2006-07-11 US disclosed
EP-1382603-A1 NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF Eisai Co., Ltd. (JP) 2004-01-21 EP disclosed