Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 14/20 | 0.49 |
| ▸ | PPARG | P37231 | 9/20 | 0.49 |
| ▸ | PPARD | Q03181 | 4/20 | 0.49 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.37 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3284688 | 0.91 | PPARA (0.41) | PPARAPPARGPPARDS1PR4S1PR1 | |
| SCHEMBL3845275 | 0.90 | PPARG (0.42) | PPARAPPARGPPARDS1PR4S1PR1 | |
| SCHEMBL3841493 | 0.85 | PPARA (0.47) | PPARAPPARGPPARD | |
| SCHEMBL3841314 | 0.85 | PPARA (0.52) | PPARAPPARGPPARD | |
| SCHEMBL3844320 | 0.85 | PPARA (0.40) | PPARAPPARGPPARD | |
| SCHEMBL3844532 | 0.79 | PPARA (0.45) | PPARAPPARGPPARD | |
| SCHEMBL3848920 | 0.78 | PPARG (0.43) | PPARAPPARGPPARD | |
| SCHEMBL3285150 | 0.77 | PPARA (0.44) | PPARAPPARGPPARD | |
| SCHEMBL3284511 | 0.77 | PPARA (0.39) | PPARAPPARGPPARDALDH1A1 | |
| SCHEMBL3841060 | 0.77 | PPARG (0.39) | PPARAPPARGS1PR4S1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856065-B1 | 1,2,4-TRIAZINE DERIVATIVES, PREPARATION AND USE THEREOF IN HUMAN THERAPY | PF MEDICAMENT (FR) | 2009-11-11 | — | — | EP | claimed |
| EP-1856065-B1 | 1,2,4-TRIAZINE DERIVATIVES, PREPARATION AND USE THEREOF IN HUMAN THERAPY | PF MEDICAMENT (FR) | 2009-11-11 | — | — | EP | disclosed |