Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.33 |
| ▸ | SYK | P43405 | 2/20 | 0.33 |
| ▸ | FASN | P49327 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | CDK9 | P50750 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3161028 | 0.78 | KDM4E (0.41) | KDM4ESMN1; SMN2ALDH1A1TSHRRAB9A | |
| SCHEMBL3160952 | 0.76 | KDM4E (0.40) | KDM4EALDH1A1TSHR | |
| SCHEMBL19117629 | 0.69 | OPRL1 (0.42) | KDM4EUSP30FASNHSD17B10SMN1; SMN2 | |
| SCHEMBL28358210 | 0.69 | KDM4E (0.40) | KDM4EALDH1A1TSHR | |
| SCHEMBL19117709 | 0.69 | USP30 (0.38) | KDM4EUSP30SYKFASNHSD17B10 | |
| SCHEMBL11354719 | 0.69 | KDM4E (0.42) | KDM4ESMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL2793256 | 0.68 | USP30 (0.44) | USP30SYKFASN | |
| SCHEMBL27648051 | 0.68 | — | — | |
| SCHEMBL7666637 | 0.67 | — | — | |
| SCHEMBL16904543 | 0.67 | USP30 (0.42) | KDM4EUSP30SYKFASNSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099754-A1 | ION CHANNEL MODULATORS | Wyeth a Corporation of the State of Delaware (US) | 2009-09-16 | — | — | EP | disclosed |
| WO-2008073929-A1 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |