Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ammonia Solution, Strong. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | F2 | P00734 | 2/20 | 0.55 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.55 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.55 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.55 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | CASP6 | P55212 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL3845772 | 1.00 | SNCA (0.62) | SNCALMNAL3MBTL1F2PRSS1 | |
| Methane SCHEMBL28785108 | 0.98 | SNCA (0.61) | SNCALMNAL3MBTL1F2PRSS1 | |
| SCHEMBL28275730 | 0.98 | SNCA (0.65) | SNCALMNAL3MBTL1F2PRSS1 | |
| Naphthalene SCHEMBL28216326 | 0.98 | SNCA (0.65) | SNCALMNAL3MBTL1F2PRSS1 | |
| SCHEMBL304050 | 0.98 | SNCA (0.65) | SNCALMNAL3MBTL1F2PRSS1 | |
| SCHEMBL29357423 | 0.98 | SNCA (0.65) | SNCALMNAL3MBTL1F2PRSS1 | |
| SCHEMBL29857297 | 0.98 | SNCA (0.65) | SNCALMNAL3MBTL1F2PRSS1 | |
| SCHEMBL1556 | 0.98 | SNCA (0.65) | SNCALMNAL3MBTL1F2PRSS1 | |
| Formaldehyde SCHEMBL10525196 | 0.96 | SNCA (0.59) | SNCALMNAL3MBTL1F2PRSS1 | |
| Hydrochloric Acid SCHEMBL3441755 | 0.96 | SNCA (0.62) | SNCALMNAL3MBTL1F2PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0426874-B1 | METHOD OF PRODUCTION OF SULFONATED HEAT-RESISTANT POLYMERIC MATERIALS | MITSUI MINING CO LTD (JP) | 1997-07-30 | — | — | EP | claimed |
| EP-0223157-B1 | IMPROVED AUTOFLUOROGRAM COMPOSITION | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1990-01-31 | — | — | EP | claimed |
| US-9687387-B2 | System and methods for treating ear disorders | YAACOBI YOSEPH (US) | 2017-06-27 | — | — | US | disclosed |
| US-20160022666-A1 | Systems and Methods for Treating Ear Disorders and Formulations Therefor | YAACOBI YOSEPH (US) | 2016-01-28 | — | — | US | disclosed |
| EP-2968999-A1 | SYSTEMS AND METHODS FOR TREATING EAR DISORDERS AND FORMULATIONS THEREFOR | Yaacobi, Yoseph (US) | 2016-01-20 | — | — | EP | disclosed |
| US-20140348959-A1 | Formulations and Methods for Treating Ear Conditions | PARTICLE SCIENCES, INC. | 2014-11-27 | — | — | US | disclosed |
| WO-2014160308-A1 | SYSTEMS AND METHODS FOR TREATING EAR DISORDERS AND FORMULATIONS THEREFOR | YAACOBI YOSEPH (US) | 2014-10-02 | — | — | WO | disclosed |
| EP-2755546-A1 | SYSTEMS AND METHODS FOR TREATING EAR DISORDERS | Yaacobi, Yoseph (US) | 2014-07-23 | — | — | EP | disclosed |
| EP-0884280-B2 | Zirconia powder, method for producing the same, and zirconia ceramics using the same | NIPPON CATALYTIC CHEM IND (JP) | 2013-10-16 | — | — | EP | disclosed |
| WO-2013123249-A2 | FORMULATIONS AND METHODS FOR TREATING EAR CONDITIONS | PARTICLE SCIENCES, INC. (US) | 2013-08-22 | — | — | WO | disclosed |
| WO-2013040352-A1 | SYSTEMS AND METHODS FOR TREATING EAR DISORDERS | YAACOBI YOSEPH (US) | 2013-03-21 | — | — | WO | disclosed |
| US-5217701-A | Process for producing carbon materials | MITSUI MINING COMPANY, LIMITED (JP) | 1993-06-08 | — | — | US | disclosed |
| US-5153000-A | Moisture retaining | KAO CORPORATION (JP) | 1992-10-06 | — | — | US | disclosed |
| US-5110899-A | Aromatic-aldehyde polysulfonates | MITSUI MINING CO., LTD. (JP) | 1992-05-05 | — | — | US | disclosed |
| EP-0426874-A1 | SULFONATED HEAT-RESISTANT POLYMERIC MATERIAL AND METHOD OF PRODUCTION THEREOF | MITSUI MINING COMPANY, LIMITED (JP) | 1991-05-15 | — | — | EP | disclosed |
| EP-0370491-A2 | Liposome comprising a novel phosphate as membrane constituent, liposome preparations and cosmetic preparations comprising said phosphate | KAO CORPORATION (JP) | 1990-05-30 | — | — | EP | disclosed |
| EP-0223157-B1 | IMPROVED AUTOFLUOROGRAM COMPOSITION | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1990-01-31 | — | — | EP | disclosed |
| EP-0304010-A2 | Process for producing carbon materials | MITSUI MINING COMPANY, LIMITED (JP) | 1989-02-22 | — | — | EP | disclosed |
| US-4710319-A | Autofluorogram composition | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1987-12-01 | — | — | US | disclosed |
| EP-0223157-A1 | Improved autofluorogram composition | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1987-05-27 | — | — | EP | disclosed |