Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 18/20 | 0.53 |
| ▸ | RAF1 | P04049 | 16/20 | 0.53 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
| ▸ | FLT4 | P35916 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13290610 | 1.00 | BRAF (0.53) | BRAFRAF1KDRLCKFYN | |
| SCHEMBL2891667 | 1.00 | BRAF (0.53) | BRAFRAF1KDRLCKFYN | |
| SCHEMBL3838807 | 1.00 | BRAF (0.53) | BRAFRAF1KDRLCKFYN | |
| SCHEMBL2890182 | 1.00 | BRAF (0.53) | BRAFRAF1KDRLCKFYN | |
| SCHEMBL13290600 | 1.00 | BRAF (0.53) | BRAFRAF1KDRLCKFYN | |
| SCHEMBL13559486 | 1.00 | BRAF (0.53) | BRAFRAF1KDRLCKFYN | |
| SCHEMBL2892976 | 0.93 | BRAF (0.53) | BRAFRAF1KDR | |
| SCHEMBL3021405 | 0.93 | BRAF (0.53) | BRAFRAF1KDR | |
| SCHEMBL3009345 | 0.93 | BRAF (0.53) | BRAFRAF1KDR | |
| SCHEMBL3009342 | 0.93 | BRAF (0.53) | BRAFRAF1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1499311-B1 | SUBSTITUTED BENZAZOLES AND USE THEREOF AS RAF KINASE INHIBITORS | NOVARTIS VACCINES & DIAGNOSTIC (US) | 2009-11-04 | — | — | EP | disclosed |