Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | APP | P05067 | 7/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | AGXT | P21549 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3400419 | 0.74 | APP (0.40) | NPC1RAB9AAPPMAOBPOLB | |
| SCHEMBL6813969 | 0.74 | NPC1 (0.55) | NPC1RAB9AAPPMAOBLMNA | |
| SCHEMBL17141565 | 0.72 | APP (0.46) | NPC1RAB9AAPPMAOBPDE2A | |
| SCHEMBL23039635 | 0.72 | NPC1 (0.43) | NPC1RAB9AAPPMAOBPDE2A | |
| SCHEMBL31533131 | 0.69 | NPC1 (0.40) | NPC1RAB9AAPPMAOBPDE2A | |
| SCHEMBL9480278 | 0.66 | APP (0.53) | NPC1RAB9AAPPMAOBIDO1 | |
| SCHEMBL22610115 | 0.66 | PDE2A (0.41) | NPC1RAB9AAPPMAOBPDE2A | |
| SCHEMBL24678411 | 0.65 | IDO1 (0.45) | MAOBIDO1AGXTPOLBSMN1; SMN2 | |
| SCHEMBL20000873 | 0.64 | APP (0.80) | NPC1RAB9AAPPMAOBIDO1 | |
| SCHEMBL20657625 | 0.63 | APP (0.51) | NPC1RAB9AAPPMAOBIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044077-A1 | DERIVATIVES AND ANALOGS OF N-ETHYLQUINOLONES AND N-ETHYLAZAQUINOLONES | Glaxo Group Limited (GB) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008009700-A1 | DERIVATIVES AND ANALOGS OF N-ETHYLQUINOLONES AND N-ETHYLAZAQUINOLONES | GLAXO GROUP LIMITED (GB) | 2008-01-24 | — | — | WO | disclosed |