Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | ITK | Q08881 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 7/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | APAF1 | O14727 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.38 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.38 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14513954 | 0.94 | SMN1; SMN2 (0.48) | NPC1RAB9ASMN1; SMN2KDM4EITK | |
| SCHEMBL3851071 | 0.88 | SMN1; SMN2 (0.51) | NPC1RAB9ASMN1; SMN2KDM4EITK | |
| SCHEMBL3844543 | 0.87 | SMN1; SMN2 (0.54) | NPC1RAB9ASMN1; SMN2KDM4EITK | |
| SCHEMBL3842440 | 0.83 | MAPK1 (0.46) | NPC1RAB9ASMN1; SMN2KDM4EITK | |
| SCHEMBL5633165 | 0.82 | SMN1; SMN2 (0.46) | NPC1RAB9ASMN1; SMN2KDM4EITK | |
| SCHEMBL3842878 | 0.81 | KDM4E (0.49) | NPC1RAB9ASMN1; SMN2KDM4EITK | |
| SCHEMBL3842312 | 0.81 | KDM4E (0.50) | NPC1RAB9ASMN1; SMN2KDM4EMAPT | |
| SCHEMBL14513948 | 0.81 | KDM4E (0.51) | NPC1RAB9ASMN1; SMN2KDM4EITK | |
| SCHEMBL3842188 | 0.81 | KDM4E (0.57) | NPC1RAB9ASMN1; SMN2KDM4EITK | |
| SCHEMBL14513963 | 0.81 | KDM4E (0.54) | NPC1RAB9ASMN1; SMN2KDM4EITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713793-A4 | PYRIMIDINONE COMPOUNDS USEFUL AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2009-09-02 | — | — | EP | claimed |
| US-20070117818-A1 | Pyrimidinone compounds useful as kinase inhibitors | HASEGAWA MASAICHI | 2007-05-24 | — | — | US | claimed |
| EP-1713793-A2 | PYRIMIDINONE COMPOUNDS USEFUL AS KINASE INHIBITORS | Smithkline Beecham Corporation (US) | 2006-10-25 | — | — | EP | claimed |
| WO-2005076854-A2 | PYRIMIDINONE COMPOUNDS USEFUL AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-08-25 | — | — | WO | claimed |
| US-20070117818-A1 | Pyrimidinone compounds useful as kinase inhibitors | HASEGAWA MASAICHI | 2007-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070117818-A1 | Pyrimidinone compounds useful as kinase inhibitors | HIPK3, HIPK1, HIPK2 | NPC1 3400/4885RAB9A 2103/4885SMN1; SMN2 1981/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.