SCHEMBL384774

SCHEMBL384774

CCCOc1cc(C(F)(F)F)ccc1O[C@H]1CCN(c2ccc(C(F)(F)F)cn2)C[C@H]1C

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SCD O00767 1/20 0.51
KDM4E B2RXH2 2/20 0.43
LMNA P02545 2/20 0.43
ABL1 P00519 1/20 0.43
HCRTR1 O43613 3/20 0.43
HCRTR2 O43614 2/20 0.43
HRH3 Q9Y5N1 2/20 0.42
SMN1; SMN2 Q16637 2/20 0.41
HPGD P15428 1/20 0.41
CHRM2 P08172 1/20 0.40
CHRM5 P08912 1/20 0.40
CHRM1 P11229 1/20 0.40
CHRM3 P20309 1/20 0.40
GPR119 Q8TDV5 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
CYP3A4 P08684 1/20 0.39
DPP4 P27487 1/20 0.39
DPP8 Q6V1X1 1/20 0.39
DPP9 Q86TI2 1/20 0.39
DPP7 Q9UHL4 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL384772 1.00 SCD (0.51) SCDKDM4ELMNAABL1HCRTR1
SCHEMBL384773 1.00 SCD (0.51) SCDKDM4ELMNAABL1HCRTR1
SCHEMBL431369 0.94 SCD (0.48) SCDKDM4ELMNAABL1HCRTR1
SCHEMBL431370 0.94 SCD (0.48) SCDKDM4ELMNAABL1HCRTR1
SCHEMBL431368 0.94 SCD (0.48) SCDKDM4ELMNAABL1HCRTR1
SCHEMBL16433638 0.94 SCD (0.45) SCDKDM4ELMNAABL1HCRTR1
SCHEMBL1726744 0.88 SCD (0.51) SCDHCRTR1HCRTR2LIPG
SCHEMBL1726740 0.88 SCD (0.51) SCDHCRTR1HCRTR2LIPG
SCHEMBL1728193 0.88 SCD (0.51) SCDHCRTR1HCRTR2LIPG
SCHEMBL1728191 0.88 SCD (0.51) SCDHCRTR1HCRTR2LIPG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE45364-E1 Cyclic amine compound and pest control agent NIPPON SODA CO., LTD. (JP) 2015-02-03 US disclosed
EP-1731518-B1 CYCLIC AMINE COMPOUND AND PEST CONTROL AGENT NIPPON SODA CO (JP) 2014-06-25 EP disclosed
EP-2650290-A1 Cyclic amine compound and pest control agent NIPPON SODA CO., LTD. (JP) 2013-10-16 EP disclosed
US-8101768-B2 Cyclic amine compound and pest control agent NIPPON SODA CO., LTD. (JP) 2012-01-24 US disclosed
US-7868178-B2 Cyclic amine compound and pest control agent NIPPON SODA CO., LTD. (JP) 2011-01-11 US disclosed
US-20090143443-A1 CYCLIC AMINE COMPOUND AND PEST CONTROL AGENT NIPPON SODA CO., LTD. (JP) 2009-06-04 US disclosed
US-7485727-B2 Cyclic amine compound and pest control agent NIPPON SODA CO., LTD. (JP) 2009-02-03 US disclosed
US-20080319003-A1 CYCLIC AMINE COMPOUND AND PEST CONTROL AGENT NIPPON SODA CO., LTD. (JP) 2008-12-25 US disclosed
US-20080045569-A1 Cyclic Amine Compound and Pest Control Agent NIPPON SODA CO., LTD. (JP) 2008-02-21 US disclosed
EP-1731518-A1 CYCLIC AMINE COMPOUND AND PEST CONTROL AGENT NIPPON SODA CO., LTD. (JP) 2006-12-13 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080045569-A1 Cyclic Amine Compound and Pest Control Agent H1-0, H1-2, H1-4 SCD 4747/4885KDM4E 373/4885LMNA 2290/4885
US-20090143443-A1 CYCLIC AMINE COMPOUND AND PEST CONTROL AGENT TAAR1, CBR3, CBR1 SCD 3537/4885KDM4E 1169/4885LMNA 3072/4885
US-20080319003-A1 CYCLIC AMINE COMPOUND AND PEST CONTROL AGENT H1-0, H1-2, H1-4 SCD 4725/4885KDM4E 339/4885LMNA 2360/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.