Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 17/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | CLK1 | P49759 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3846486 | 0.91 | KIT (0.39) | KIT | |
| SCHEMBL3849392 | 0.91 | MAP4K4 (0.35) | MAP4K4CLK1 | |
| Hydrochloric Acid SCHEMBL3846886 | 0.89 | MAP4K4 (0.34) | KITMAP4K4 | |
| SCHEMBL3846459 | 0.87 | KIT (0.37) | KITMAP4K4RAF1BRAFCLK1 | |
| SCHEMBL4715276 | 0.86 | KIT (0.38) | KITMAP4K4 | |
| Hydrochloric Acid SCHEMBL3854735 | 0.85 | KIT (0.38) | KITMAP4K4 | |
| SCHEMBL3854332 | 0.83 | KIT (0.35) | KIT | |
| SCHEMBL3847588 | 0.82 | KIT (0.35) | KIT | |
| SCHEMBL3852540 | 0.81 | STK17B (0.33) | KITMAP4K4 | |
| Hydrochloric Acid SCHEMBL3856201 | 0.81 | CA12 (0.33) | KITMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |