Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 6/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | AKT2 | P31751 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 8/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3846734 | 0.90 | MKNK1 (0.44) | FLT3AKT1AKT2TGFBR1FYN | |
| SCHEMBL3846448 | 0.88 | FLT3 (0.44) | FLT3AKT1AKT2TGFBR1FYN | |
| SCHEMBL3849014 | 0.88 | AKT1 (0.41) | FLT3AKT1AKT2TGFBR1 | |
| SCHEMBL3848374 | 0.88 | FYN (0.45) | FLT3AKT1AKT2TGFBR1FYN | |
| SCHEMBL3845520 | 0.88 | FLT3 (0.41) | FLT3AKT1AKT2TGFBR1FYN | |
| SCHEMBL3845550 | 0.88 | FLT3 (0.41) | FLT3AKT1AKT2TGFBR1FYN | |
| SCHEMBL3846108 | 0.88 | FLT3 (0.41) | FLT3AKT1AKT2TGFBR1FYN | |
| SCHEMBL3845957 | 0.88 | FLT3 (0.41) | FLT3AKT1AKT2TGFBR1 | |
| SCHEMBL3849706 | 0.88 | FLT3 (0.46) | FLT3AKT1AKT2FYNMAPK14 | |
| SCHEMBL3845245 | 0.87 | FLT3 (0.39) | FLT3AKT1AKT2TGFBR1TGFBR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |