Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 5/20 | 0.72 |
| ▸ | BRAF | P15056 | 5/20 | 0.72 |
| ▸ | KDR | P35968 | 5/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.64 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.64 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.64 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | ABL1 | P00519 | 2/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.62 |
| ▸ | HTT | P42858 | 2/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.62 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.62 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.55 |
| ▸ | TUBB | P07437 | 3/20 | 0.55 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.55 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20525713 | 0.90 | RAF1 (0.73) | RAF1BRAFKDRMAPK1ADORA3 | |
| SCHEMBL3471881 | 0.90 | RAF1 (0.59) | RAF1BRAFKDRMAPK1ADORA3 | |
| SCHEMBL20525779 | 0.89 | RAF1 (0.72) | RAF1BRAFKDRMAPK1ADORA3 | |
| SCHEMBL20525848 | 0.87 | RAF1 (0.70) | RAF1BRAFKDRMAPK1ADORA3 | |
| SCHEMBL20525589 | 0.87 | RAF1 (0.70) | RAF1BRAFKDRMAPK1ADORA3 | |
| SCHEMBL20525682 | 0.86 | RAF1 (0.69) | RAF1BRAFKDRMAPK1ADORA3 | |
| SCHEMBL3857512 | 0.86 | RAF1 (0.66) | RAF1BRAFKDRMAPK1ADORA3 | |
| SCHEMBL1791971 | 0.81 | RAF1 (0.64) | RAF1BRAFKDRMAPK1ADORA3 | |
| SCHEMBL2357955 | 0.81 | RAF1 (0.63) | RAF1BRAFKDRMAPK1LMNA | |
| SCHEMBL1468134 | 0.81 | RAF1 (0.49) | RAF1BRAFMAPK1LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2101759-A1 | METHODS OF USING MEK INHIBITORS | Exelixis, Inc. (US) | 2009-09-23 | — | — | EP | claimed |
| WO-2008076415-A1 | METHODS OF USING MEK INHIBITORS | EXELIXIS, INC. (US) | 2008-06-26 | — | — | WO | claimed |