Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 18/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 16/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 17/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 16/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 16/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 15/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 14/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 14/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 13/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 13/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 13/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.45 |
| ▸ | INSR | P06213 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3850621 | 0.91 | HDAC1 (0.53) | HDAC1HDAC6HDAC2HDAC8HDAC3 | |
| SCHEMBL3848328 | 0.91 | HDAC1 (0.59) | HDAC1HDAC6HDAC2HDAC8HDAC3 | |
| SCHEMBL296547 | 0.91 | HDAC1 (0.55) | HDAC1HDAC6HDAC2HDAC8HDAC3 | |
| SCHEMBL296548 | 0.91 | HDAC1 (0.55) | HDAC1HDAC6HDAC2HDAC8HDAC3 | |
| SCHEMBL3145473 | 0.88 | HDAC1 (0.51) | HDAC1HDAC6HDAC2HDAC8HDAC3 | |
| SCHEMBL3145488 | 0.88 | HDAC1 (0.51) | HDAC1HDAC6HDAC2HDAC8HDAC3 | |
| SCHEMBL3146007 | 0.85 | HDAC1 (0.58) | HDAC1HDAC6HDAC2HDAC8HDAC3 | |
| SCHEMBL3146017 | 0.85 | HDAC1 (0.58) | HDAC1HDAC6HDAC2HDAC8HDAC3 | |
| SCHEMBL296243 | 0.85 | HDAC1 (0.52) | HDAC1HDAC6HDAC2HDAC8HDAC3 | |
| SCHEMBL296244 | 0.85 | HDAC1 (0.52) | HDAC1HDAC6HDAC2HDAC8HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1861365-B1 | N-SULPHONYLPYRROLES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS | 4SC AG (DE) | 2009-07-01 | — | — | EP | claimed |