Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 18/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 17/20 | 0.49 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.46 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL215612 | 0.86 | CDK1 (0.57) | HSP90AB1HSP90AA1 | |
| SCHEMBL30759944 | 0.82 | FGFR1 (0.63) | HSP90AB1HSP90AA1HDAC6HDAC4HDAC1 | |
| SCHEMBL1566036 | 0.82 | FGFR1 (0.63) | HSP90AB1HSP90AA1HDAC6HDAC4HDAC1 | |
| SCHEMBL31167347 | 0.80 | HSP90AB1 (0.44) | HSP90AB1HSP90AA1HSP90B1TRAP1HDAC6 | |
| SCHEMBL217726 | 0.80 | POLB (0.45) | — | |
| SCHEMBL2098713 | 0.79 | HSP90AB1 (0.53) | HSP90AB1HSP90AA1HSP90B1TRAP1HDAC6 | |
| SCHEMBL2916205 | 0.79 | HSP90AB1 (0.53) | HSP90AB1HSP90AA1HSP90B1TRAP1HDAC6 | |
| SCHEMBL31058755 | 0.79 | HDAC6 (0.54) | HSP90AB1HSP90AA1HDAC6HDAC4HDAC1 | |
| SCHEMBL24316894 | 0.78 | POLB (0.56) | HSP90AB1HSP90AA1HSP90B1TRAP1HDAC6 | |
| SCHEMBL6837990 | 0.78 | HSP90AB1 (0.43) | HSP90AB1HSP90AA1HSP90B1TRAP1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831235-B1 | LUNG-TARGETED DRUGS | UNIV CALIFORNIA (US) | 2013-02-20 | — | — | EP | disclosed |
| US-8318700-B2 | Lung-targeted drugs | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-11-27 | — | — | US | disclosed |
| US-20120122818-A1 | LUNG-TARGETED DRUGS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-05-17 | — | — | US | disclosed |
| US-8101745-B2 | Conjugate cidofovir, idoxuridine, vidarabine, trifluridine, acyclovir, famciclovir penciclovir, valacyclovir, ganciclovir, antiviral, antimicrobial, cancer drug of interest to glycerol ethers or glycerol phosphate ethers | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-01-24 | — | — | US | disclosed |
| US-20080221061-A1 | Lung-Targeted Drugs | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-09-11 | — | — | US | disclosed |
| EP-1831235-A2 | LUNG-TARGETED DRUGS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066074-A2 | LUNG-TARGETED DRUGS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2006-06-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221061-A1 | Lung-Targeted Drugs | DGKG, GK, PHOSPHO1 | HSP90AB1 825/4885HSP90AA1 1180/4885HSP90B1 295/4885 |
| US-20120122818-A1 | LUNG-TARGETED DRUGS | DGKG, GK, PHOSPHO1 | HSP90AB1 825/4885HSP90AA1 1180/4885HSP90B1 295/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.