Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 6/20 | 0.77 |
| ▸ | MCHR1 | Q99705 | 6/20 | 0.77 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 6/20 | 0.48 |
| ▸ | GPR183 | P32249 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3865017 | 1.00 | CHRM1 (0.77) | CHRM1MCHR1HRH3GAAL3MBTL1 | |
| SCHEMBL3857997 | 0.91 | MCHR1 (0.78) | CHRM1MCHR1HRH3HTR2AGPR183 | |
| SCHEMBL3866261 | 0.89 | CHRM1 (0.73) | CHRM1MCHR1GAAHTR2AGPR183 | |
| SCHEMBL3857803 | 0.89 | CHRM1 (0.73) | CHRM1MCHR1GAAHTR2AGPR183 | |
| SCHEMBL3866721 | 0.88 | CHRM1 (0.72) | CHRM1MCHR1HRH3GAAL3MBTL1 | |
| SCHEMBL3863166 | 0.88 | CHRM1 (0.71) | CHRM1MCHR1GAAHTR2AGPR183 | |
| SCHEMBL3859239 | 0.88 | MCHR1 (0.98) | CHRM1MCHR1HRH3HTR2AGPR183 | |
| SCHEMBL3865169 | 0.88 | MCHR1 (0.60) | CHRM1MCHR1HRH3GAAL3MBTL1 | |
| SCHEMBL3859584 | 0.88 | MCHR1 (0.59) | CHRM1MCHR1HRH3HTR2AGPR183 | |
| SCHEMBL3866522 | 0.87 | MCHR1 (0.80) | CHRM1MCHR1HRH3GAAHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7592373-B2 | Amide compounds with MCH antagonistic activity and medicaments comprising these compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-09-22 | — | — | US | disclosed |
| US-20050267093-A1 | Amide compounds with MCH antagonistic activity and medicaments comprising these compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-12-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050267093-A1 | Amide compounds with MCH antagonistic activity and medicaments comprising these compounds | MCHR1, MC4R, MCHR2 | CHRM1 103/4885MCHR1 1/4885HRH3 129/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.