Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | DAO | P14920 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6201226 | 1.00 | GAA (0.54) | GAATSHRHSD17B10RAB9AHPGD | |
| SCHEMBL6201220 | 1.00 | GAA (0.54) | GAATSHRHSD17B10RAB9AHPGD | |
| SCHEMBL3866711 | 1.00 | GAA (0.54) | GAATSHRHSD17B10RAB9AHPGD | |
| SCHEMBL6201485 | 0.85 | GAA (0.52) | GAATSHRHSD17B10RAB9AHPGD | |
| SCHEMBL6201483 | 0.85 | GAA (0.52) | GAATSHRHSD17B10RAB9AHPGD | |
| SCHEMBL6201474 | 0.85 | GAA (0.52) | GAATSHRHSD17B10RAB9AHPGD | |
| SCHEMBL16615455 | 0.83 | GAA (0.53) | GAATSHRHSD17B10RAB9AHPGD | |
| SCHEMBL7825593 | 0.81 | GAA (0.39) | GAATSHRHSD17B10RAB9AHPGD | |
| SCHEMBL7825597 | 0.81 | GAA (0.39) | GAATSHRHSD17B10RAB9AHPGD | |
| SCHEMBL7005733 | 0.79 | TSHR (0.57) | GAATSHRHSD17B10RAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7592467-B2 | Inhibitors of prolyl endopeptidase | PROBIODRUG AG (DE) | 2009-09-22 | — | — | US | disclosed |
| EP-1869008-A1 | INHIBITORS OF PROLYL ENDOPEPTIDASE | Probiodrug AG (DE) | 2007-12-26 | — | — | EP | disclosed |
| WO-2006120104-A1 | INHIBITORS OF PROLYL ENDOPEPTIDASE | PROBIODRUG AG (DE) | 2006-11-16 | — | — | WO | disclosed |
| US-20060229357-A1 | Compounds | PROBIODRUG AG | 2006-10-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060229357-A1 | Compounds | PREP, BACE1, MME | GAA 10/4885TSHR 2649/4885HSD17B10 782/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.