SCHEMBL385982

SCHEMBL385982

O=C(O)C1C=Cc2ccccc2N1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.40
GAA P10253 2/20 0.40
HSPA1A P0DMV8 1/20 0.36
PTPN7 P35236 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
ALDH1A1 P00352 4/20 0.34
MEN1 O00255 3/20 0.34
KMT2A Q03164 3/20 0.34
RAB9A P51151 3/20 0.34
SMN1; SMN2 Q16637 3/20 0.34
KDM4E B2RXH2 2/20 0.34
MAPK1 P28482 2/20 0.34
NPC1 O15118 1/20 0.34
TP53 P04637 1/20 0.34
HPGD P15428 1/20 0.34
ALOX15 P16050 1/20 0.34
P2RX4 Q99571 1/20 0.34
EGFR P00533 2/20 0.33
ATM Q13315 1/20 0.33
HSD17B10 Q99714 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7435031 0.98 MAPT (0.39) MAPTGAAHSPA1APTPN7TDP1
SCHEMBL1286805 0.84 MAPT (0.38) MAPTGAAALDH1A1MEN1KMT2A
SCHEMBL27348437 0.84 MAPT (0.38) MAPTGAAALDH1A1MEN1KMT2A
SCHEMBL31301236 0.84 MAPT (0.38) MAPTGAAALDH1A1MEN1KMT2A
2-Pyrrolidone SCHEMBL27602198 0.83 OR51E2 (0.39) MAPTGAAHSPA1APTPN7TDP1
Hydrochloric Acid SCHEMBL27965612 0.82 MAPT (0.36) MAPTGAAALDH1A1RAB9ASMN1; SMN2
SCHEMBL3250625 0.80 MAPT (0.40) MAPTGAAALDH1A1MEN1KMT2A
SCHEMBL14603902 0.80 P2RX4 (0.37) MAPTGAAMEN1KMT2ARAB9A
SCHEMBL8700492 0.78 CYP1A2 (0.42) GAAALDH1A1MEN1KMT2ARAB9A
SCHEMBL28219643 0.77 FABP7 (0.43) TDP1ALDH1A1KMT2AMAPK1P2RX4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 170 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105051013-A Laquinimod sodium crystals and improved process for their manufacture TEVA PHARMA 2015-11-11 CN claimed
CN-102964301-A Method for synthesizing IOX2 CGENE TECH SUZHOU CHINA CO LTD 2013-03-13 CN claimed
EP-2323978-A1 AMIDE COMPOUND Takeda Pharmaceutical Company Limited (JP) 2011-05-25 EP claimed
WO-2010018874-A1 AMIDE COMPOUND TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2010-02-18 WO claimed
CN-101431998-A Containing CBxPharmaceutical compositions of cannabinoid receptor modulators and potassium channel modulators SOLVAY PHARM GMBH (DE) 2009-05-13 CN claimed
EP-1807422-A1 5-HT4 RECEPTOR AGONIST COMPOUNDS Theravance, Inc. (US) 2007-07-18 EP claimed
WO-2006052640-A1 5-HT4 RECEPTOR AGONIST COMPOUNDS THERAVANCE, INC. (US) 2006-05-18 WO claimed
EP-1534703-A2 ANTAGONISTS OF MELANIN CONCENTRATING HORMONE RECEPTOR ABBOTT LABORATORIES (US) 2005-06-01 EP claimed
EP-1478645-A2 QUINOLINONE DERIVATIVES FOR TREATING CELL PROLIFERATION RELATED DISORDERS Amgen Inc. (US) 2004-11-24 EP claimed
WO-2003106452-A2 ANTAGONISTS OF MELANIN CONCENTRATING HORMONE RECEPTOR MILLENNIUM PHARMACEUTICALS, INC. (US) 2003-12-24 WO claimed
WO-2003066630-A2 QUINOLINONE DERIVATIVES FOR TREATING CELL PROLIFERATION RELATED DISORDERS AMGEN INC. (US) 2003-08-14 WO claimed
CN-1337950-A 2-oxoquinoline compounds and medicinal uses thereof JAPAN TOBACCO INC (JP) 2002-02-27 CN claimed
EP-0885232-A1 NOVEL 1(2H) QUINOLINE CARBOXYLIC ACID DERIVATIVES, METHOD FOR PREPARING SAME, AND USE THEREOF FOR SYNTHESISING SUBSTANCES HAVING ANTIBIOTIC PROPERTIES HOECHST MARION ROUSSEL (FR) 1998-12-23 EP claimed
WO-1997031926-A1 NOVEL 1(2H) QUINOLINE CARBOXYLIC ACID DERIVATIVES, METHOD FOR PREPARING SAME, AND USE THEREOF FOR SYNTHESISING SUBSTANCES HAVING ANTIBIOTIC PROPERTIES HOECHST MARION ROUSSEL (FR) 1997-09-04 WO claimed
WO-2023165373-A1 MICROMOLECULAR PCSK9 PROTEIN DEGRADATION AGENT, PREPARATION METHOD THEREFOR, AND USE THEREOF 复旦大学 2023-09-07 WO disclosed
EP-4232444-A1 HETEROCYCLIC SPIRO COMPOUNDS AND METHODS OF USE Amgen Inc. (US) 2023-08-30 EP disclosed
EP-4126844-A1 AMIDE COMPOUNDS AND USES THEREOF Hutchison Medipharma Limited (CN) 2023-02-08 EP disclosed
EP-0303387-A1 Kynurenic acid derivatives useful in the treatment of neurodegenerative disorders MERCK SHARP & DOHME LTD. (GB) 1989-02-15 EP disclosed
CN-1030237-A BENZOHETEROCYCLIC COMPOUNDS OTSUKA PHARMA CO LTD (JP) 1989-01-11 CN disclosed
EP-0287951-A2 7-Piperazinyl- or 7-Morpholino-4-oxo-quinoline-3-carboxylic acid derivatives, their preparation and their use as antimicrobial agents OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1988-10-26 EP disclosed