Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 13/20 | 0.48 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ICMT | O60725 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL250298 | 0.83 | CNR2 (0.61) | CNR2CNR1 | |
| SCHEMBL2736732 | 0.81 | CNR2 (0.58) | CNR2CNR1ALDH1A1HPGD | |
| SCHEMBL218381 | 0.78 | CNR2 (0.43) | CNR2CNR1ALDH1A1MEN1KMT2A | |
| SCHEMBL1522903 | 0.78 | CNR2 (0.57) | CNR2CNR1NPC1ALDH1A1RAB9A | |
| SCHEMBL2760181 | 0.77 | CNR2 (0.64) | CNR2CNR1HPGDMEN1KMT2A | |
| SCHEMBL2736892 | 0.77 | CNR2 (0.54) | CNR2CNR1NPC1RAB9AMEN1 | |
| SCHEMBL2736850 | 0.77 | CNR2 (0.60) | CNR2CNR1ALDH1A1HPGD | |
| SCHEMBL2736805 | 0.77 | CNR2 (0.58) | CNR2CNR1 | |
| SCHEMBL858856 | 0.77 | CNR2 (0.64) | CNR2CNR1 | |
| Hydrochloric Acid SCHEMBL11537392 | 0.77 | CNR2 (0.56) | CNR2CNR1NPC1ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2130820-A1 | Antipruritics | SHIONOGI & CO., LTD. (JP) | 2009-12-09 | — | — | EP | disclosed |
| EP-1477186-B1 | ANTIPRURITICS | SHIONOGI & CO (JP) | 2009-11-11 | — | — | EP | disclosed |