Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 12/20 | 0.58 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.58 |
| ▸ | SMC2 | O95347 | 1/20 | 0.58 |
| ▸ | EGFR | P00533 | 1/20 | 0.58 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.58 |
| ▸ | SMC1A | Q14683 | 1/20 | 0.58 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.58 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.58 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.58 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | NQO2 | P16083 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27601206 | 0.84 | MAP2K1 (0.64) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| SCHEMBL3864000 | 0.83 | MAP2K1 (0.55) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| SCHEMBL2277841 | 0.83 | MAP2K1 (0.60) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| SCHEMBL1042320 | 0.82 | MAP2K1 (0.53) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| SCHEMBL19014958 | 0.81 | MAP2K1 (0.61) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| SCHEMBL26937949 | 0.81 | MAP2K1 (0.69) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| SCHEMBL3860279 | 0.81 | MAP2K1 (0.55) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| SCHEMBL1488195 | 0.81 | MAP2K1 (0.71) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| SCHEMBL30746854 | 0.81 | MAP2K1 (0.71) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 | |
| SCHEMBL30733259 | 0.81 | MAP2K1 (0.71) | MAP2K1MAP2K2SMC2EGFRCSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1482932-A4 | N3 ALKYLATED BENZIMIDAZOLE DERIVATIVES AS MEK INHIBITORS | ARRAY BIOPHARMA INC (US) | 2006-04-05 | — | — | EP | claimed |
| EP-1482932-A1 | N3 ALKYLATED BENZIMIDAZOLE DERIVATIVES AS MEK INHIBITORS | Array Biopharma, Inc. (US) | 2004-12-08 | — | — | EP | claimed |
| WO-2003077914-A1 | N3 ALKYLATED BENZIMIDAZOLE DERIVATIVES AS MEK INHIBITORS | ARRAY BIOPHARMA, INC (US) | 2003-09-25 | — | — | WO | claimed |
| EP-2739358-A1 | METHODS OF TREATING CANCER USING PD-1 AXIS BINDING ANTAGONISTS AND MEK INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-06-11 | — | — | EP | disclosed |
| WO-2013019906-A9 | METHODS OF TREATING CANCER USING PD-1 AXIS BINDING ANTAGONISTS AND MEK INHIBITORS | GENENTECH, INC. (US) | 2014-03-20 | — | — | WO | disclosed |
| WO-2013019906-A1 | METHODS OF TREATING CANCER USING PD-1 AXIS BINDING ANTAGONISTS AND MEK INHIBITORS | GENENTECH, INC. (US) | 2013-02-07 | — | — | WO | disclosed |
| EP-1663210-A4 | N3 ALKYLATED BENZIMIDAZOLE DERIVATIVES AS MEK INHIBITORS | ARRAY BIOPHARMA INC (US) | 2009-04-22 | — | — | EP | disclosed |
| EP-1663210-A1 | N3 ALKYLATED BENZIMIDAZOLE DERIVATIVES AS MEK INHIBITORS | Array Biopharma, Inc. (US) | 2006-06-07 | — | — | EP | disclosed |
| EP-1482932-A4 | N3 ALKYLATED BENZIMIDAZOLE DERIVATIVES AS MEK INHIBITORS | ARRAY BIOPHARMA INC (US) | 2006-04-05 | — | — | EP | disclosed |
| WO-2005023251-A1 | N3 ALKYLATED BENZIMIDAZOLE DERIVATIVES AS MEK INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2005-03-17 | — | — | WO | disclosed |
| EP-1482932-A1 | N3 ALKYLATED BENZIMIDAZOLE DERIVATIVES AS MEK INHIBITORS | Array Biopharma, Inc. (US) | 2004-12-08 | — | — | EP | disclosed |
| WO-2003077914-A1 | N3 ALKYLATED BENZIMIDAZOLE DERIVATIVES AS MEK INHIBITORS | ARRAY BIOPHARMA, INC (US) | 2003-09-25 | — | — | WO | disclosed |