Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | CPS1 | P31327 | 2/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 3/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.39 |
| ▸ | FASN | P49327 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2103549 | 0.90 | PTGDR2 (0.54) | PTGDR2CPS1EPHX2KCNH2HRH3 | |
| SCHEMBL3862752 | 0.89 | PTGDR2 (0.48) | PTGDR2CPS1KCNH2HRH3HPGD | |
| SCHEMBL3858332 | 0.89 | PTGDR2 (0.48) | PTGDR2KCNH2HRH3HPGDCNR1 | |
| SCHEMBL2100248 | 0.85 | CPS1 (0.53) | CPS1EPHX2KCNH2HRH3HPGD | |
| SCHEMBL2102664 | 0.83 | PTGDR2 (0.54) | PTGDR2KCNH2HRH3HPGDTSHR | |
| SCHEMBL2099200 | 0.80 | HPGD (0.47) | CPS1EPHX2KCNH2HRH3HPGD | |
| SCHEMBL2101859 | 0.79 | PTGDR2 (0.60) | PTGDR2CPS1KCNH2HRH3HPGD | |
| SCHEMBL2099785 | 0.79 | PTGDR2 (0.60) | PTGDR2KCNH2HRH3HPGDTSHR | |
| SCHEMBL2099228 | 0.78 | TSHR (0.52) | PTGDR2HPGDSCN9ATSHRALDH1A1 | |
| SCHEMBL2101312 | 0.78 | PTGDR2 (0.52) | PTGDR2EPHX2HPGDFASNTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784388-B3 | BIPHENYLOXYACETIC ACID DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASE | ASTRAZENECA AB (SE) | 2012-09-05 | — | — | EP | disclosed |
| EP-1784388-B1 | BIPHENYLOXYACETIC ACID DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASE | ASTRAZENECA AB (SE) | 2009-11-04 | — | — | EP | disclosed |
| EP-1784388-A1 | BIPHENYLOXYACETIC ACID DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASE | AstraZeneca AB (SE) | 2007-05-16 | — | — | EP | disclosed |
| WO-2006021759-A1 | BIPHENYLOXYACETIC ACID DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASE | ASTRAZENECA AB (SE) | 2006-03-02 | — | — | WO | disclosed |