Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HAO1 | Q9UJM8 | 7/20 | 0.51 |
| ▸ | ACACB | O00763 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | PTGES | O14684 | 2/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3860671 | 0.99 | HAO1 (0.50) | HAO1ACACBKCNH2BACE1PTGES | |
| SCHEMBL236004 | 0.85 | HAO1 (0.47) | HAO1ACACBKCNH2BACE1PTGES | |
| SCHEMBL236010 | 0.85 | HAO1 (0.47) | HAO1ACACBKCNH2BACE1PTGES | |
| SCHEMBL237227 | 0.84 | HAO1 (0.46) | HAO1ACACBKCNH2BACE1PTGES | |
| SCHEMBL233852 | 0.75 | HAO1 (0.47) | HAO1KCNH2BACE1PDGFRBPDGFRA | |
| SCHEMBL237026 | 0.75 | HAO1 (0.47) | HAO1KCNH2BACE1PDGFRBPDGFRA | |
| SCHEMBL235488 | 0.75 | HAO1 (0.47) | HAO1KCNH2BACE1PDGFRBPDGFRA | |
| SCHEMBL236498 | 0.73 | HAO1 (0.46) | HAO1KCNH2PDGFRBPDGFRAGRM5 | |
| SCHEMBL23025713 | 0.72 | HAO1 (0.49) | HAO1PTGESFFAR1FFAR4 | |
| SCHEMBL3862174 | 0.72 | HAO1 (0.43) | HAO1ACACBBACE1PTGESGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076122-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2009-07-08 | — | — | EP | disclosed |
| WO-2009005794-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2009-01-08 | — | — | WO | disclosed |