Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 12/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL237218 | 0.84 | GRM5 (0.38) | GRM5ALDH1A1POLBNPC1RAB9A | |
| SCHEMBL234994 | 0.83 | MAP3K14 (0.37) | GRM5MEN1ALDH1A1LMNAPOLB | |
| SCHEMBL235267 | 0.80 | MAP3K14 (0.39) | GRM5MEN1ALDH1A1LMNAPOLB | |
| SCHEMBL13559261 | 0.80 | MAP3K14 (0.39) | GRM5MEN1ALDH1A1LMNAPOLB | |
| SCHEMBL233593 | 0.79 | POLB (0.39) | MEN1ALDH1A1LMNAPOLBMAPT | |
| SCHEMBL235310 | 0.79 | POLB (0.39) | MEN1ALDH1A1LMNAPOLBMAPT | |
| SCHEMBL234761 | 0.79 | POLB (0.39) | MEN1ALDH1A1LMNAPOLBMAPT | |
| SCHEMBL3837462 | 0.79 | GRM5 (0.40) | GRM5MEN1ALDH1A1LMNAPOLB | |
| Hydrochloric Acid SCHEMBL28053019 | 0.78 | GRM5 (0.39) | GRM5MEN1ALDH1A1LMNAPOLB | |
| SCHEMBL2151065 | 0.77 | POLB (0.38) | GRM5MEN1ALDH1A1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076122-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2009-07-08 | — | — | EP | disclosed |
| WO-2009005794-A2 | ALKYNYL PHENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2009-01-08 | — | — | WO | disclosed |