⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3874819 | 1.00 | — | — | |
| SCHEMBL3874816 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL5498424 | 0.98 | TSHR (0.37) | — | |
| SCHEMBL6591413 | 0.82 | TSHR (0.36) | — | |
| SCHEMBL27563341 | 0.82 | TSHR (0.36) | — | |
| SCHEMBL28262576 | 0.81 | — | — | |
| SCHEMBL2241969 | 0.81 | — | — | |
| SCHEMBL3117265 | 0.78 | — | — | |
| SCHEMBL12116983 | 0.78 | — | — | |
| SCHEMBL485564 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7576234-B2 | Michael-type addition of a nucleophile to a dialkyl 2-methylidenylpropan-1,3-dioate and the conversion of a ester moiety into an amino moiety; S)-2-methylcysteine; desferrithiocin | GENZYME CORPORATION (US) | 2009-08-18 | — | — | US | disclosed |
| US-7285676-B2 | Synthesis of chiral 2-alkyl amino acids | GENZYME CORPORATION (US) | 2007-10-23 | — | — | US | disclosed |
| US-20060167267-A1 | Synthesis of 2-alkyl amino acids | CHORGHADE MUKUND S | 2006-07-27 | — | — | US | disclosed |
| US-20060142586-A1 | Synthesis of 2-alkyl amino acids | CHORGHADE MUKUND S | 2006-06-29 | — | — | US | disclosed |
| US-7038073-B2 | Synthesis of 2-alkyl amino acids | GENZYME CORPORATION (US) | 2006-05-02 | — | — | US | disclosed |
| US-20060069265-A1 | Synthesis of chiral 2-alkyl amino acids | GENZYME CORPORATION (US) | 2006-03-30 | — | — | US | disclosed |
| US-7002036-B2 | Synthesis of 2-alkyl amino acids | GENZYME CORPORATION (US) | 2006-02-21 | — | — | US | disclosed |
| US-6903220-B2 | Synthesis of chiral 2-alkyl amino acids | GENZYME CORPORATION (US) | 2005-06-07 | — | — | US | disclosed |
| EP-1529037-A2 | SYNTHESIS OF 2-ALKYLCYSTEINES, 2-(HYDROXYLATED PHENYL)-4-ALKYLTHIAZOLINE-4-CARBOXYLIC ACIDS AND DERIVATIVES THEREOF | Genzyme Corporation (US) | 2005-05-11 | — | — | EP | disclosed |
| US-20040024224-A1 | Synthesis of 2-alkyl amino acids | GENZYME CORPORATION (US) | 2004-02-05 | — | — | US | disclosed |
| US-20040006224-A1 | Synthesis of 2-alkyl amino acids | GENZYME CORPORATION | 2004-01-08 | — | — | US | disclosed |
| US-20030225287-A1 | Synthesis of chiral 2-alkyl amino acids | GENZYME CORPORATION | 2003-12-04 | — | — | US | disclosed |
| WO-2003097622-A2 | SYNTHESIS OF 2-ALKYLCYSTEINES, 2-(HYDROXYLATED PHENYL)-4-ALKYLTHIAZOLINE-4-CARBOXYLIC ACIDS AND DERIVATIVES THEREOF | GENZYME CORPORATION (US) | 2003-11-27 | — | — | WO | disclosed |