Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 15/20 | 0.48 |
| ▸ | CDK1 | P06493 | 12/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 12/20 | 0.48 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.46 |
| ▸ | CDK4 | P11802 | 1/20 | 0.44 |
| ▸ | CCND1 | P24385 | 1/20 | 0.44 |
| ▸ | CCND2 | P30279 | 1/20 | 0.44 |
| ▸ | CCND3 | P30281 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | MERTK | Q12866 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1353780 | 0.89 | EIF2AK4 (0.60) | AURKACDK1CCNB1EIF2AK4CDK4 | |
| SCHEMBL1355910 | 0.82 | FGFR4 (0.50) | AURKACDK1CCNB1EIF2AK4CDK4 | |
| SCHEMBL1353825 | 0.82 | AURKA (0.46) | AURKACDK1CCNB1EIF2AK4CDK4 | |
| SCHEMBL1355521 | 0.82 | AURKA (0.46) | AURKACDK1CCNB1EIF2AK4CYP3A4 | |
| SCHEMBL1355254 | 0.82 | AURKA (0.44) | AURKACDK1CCNB1EIF2AK4CDK4 | |
| SCHEMBL1356204 | 0.82 | PLK2 (0.45) | AURKACDK1CCNB1EIF2AK4FLT3 | |
| SCHEMBL1356007 | 0.81 | EIF2AK4 (0.67) | AURKAEIF2AK4CDK4CCND1CCND2 | |
| SCHEMBL3591861 | 0.81 | AURKA (0.54) | AURKACDK1CCNB1CDK4CCND1 | |
| SCHEMBL1356818 | 0.81 | EIF2AK4 (0.58) | AURKACDK1CCNB1EIF2AK4CDK4 | |
| SCHEMBL1353936 | 0.80 | AURKA (0.49) | AURKAEIF2AK4CDK4CCND1CCND2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2108020-A2 | 1-H-PYRAZOLO[3,4B]PYRIMIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF MITOTIC KINASES | Biogen Idec MA, Inc. (US) | 2009-10-14 | — | — | EP | claimed |
| WO-2008094602-A2 | 1-H-PYRAZOLO (3,4B) PYRIMIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF MITOTIC KINASES | BIOGEN IDEC MA INC. (US) | 2008-08-07 | — | — | WO | claimed |