Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 2/20 | 0.43 |
| ▸ | CCND1 | P24385 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12002193 | 0.81 | KDM4E (0.78) | KDM4EALDH1A1HPGDSMN1; SMN2PDE3B | |
| SCHEMBL2798796 | 0.81 | KDM4E (0.58) | KDM4EALDH1A1HPGDSMN1; SMN2PDE3B | |
| SCHEMBL12002191 | 0.78 | KDM4E (0.58) | KDM4EALDH1A1HPGDSMN1; SMN2PDE3B | |
| SCHEMBL30908532 | 0.77 | TNKS2 (0.46) | KDM4EALDH1A1HPGDSMN1; SMN2PDE3B | |
| SCHEMBL30810554 | 0.77 | TNKS2 (0.45) | KDM4EALDH1A1HPGDSMN1; SMN2PDE3B | |
| SCHEMBL705758 | 0.77 | TNKS2 (0.45) | KDM4EALDH1A1HPGDSMN1; SMN2PDE3B | |
| SCHEMBL14279689 | 0.76 | KDM4E (0.61) | KDM4EALDH1A1HPGDSMN1; SMN2PDE3B | |
| SCHEMBL2797608 | 0.75 | KDM4E (0.51) | KDM4EALDH1A1HPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL25904127 | 0.75 | PDE3B (0.50) | KDM4EALDH1A1HPGDSMN1; SMN2PDE3B | |
| SCHEMBL706591 | 0.74 | PDE3B (0.43) | KDM4EALDH1A1HPGDSMN1; SMN2PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044077-A1 | DERIVATIVES AND ANALOGS OF N-ETHYLQUINOLONES AND N-ETHYLAZAQUINOLONES | Glaxo Group Limited (GB) | 2009-04-08 | — | — | EP | claimed |
| WO-2008009700-A1 | DERIVATIVES AND ANALOGS OF N-ETHYLQUINOLONES AND N-ETHYLAZAQUINOLONES | GLAXO GROUP LIMITED (GB) | 2008-01-24 | — | — | WO | claimed |