Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 10/20 | 0.68 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | CNR2 | P34972 | 3/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3858076 | 0.89 | SERPINE1 (0.85) | SERPINE1SCN9AIDO1THRBPDE4A | |
| SCHEMBL4750090 | 0.83 | SERPINE1 (0.83) | SERPINE1IDO1RXRARXRB | |
| SCHEMBL3862674 | 0.83 | CNR2 (0.54) | SERPINE1CNR2 | |
| Tiplasinin SCHEMBL29448190 | 0.82 | SERPINE1 (1.00) | SERPINE1 | |
| Tiplasinin SCHEMBL3052065 | 0.82 | SERPINE1 (1.00) | SERPINE1 | |
| SCHEMBL4752947 | 0.81 | SERPINE1 (1.00) | SERPINE1IDO1RXRARXRB | |
| SCHEMBL3868588 | 0.79 | SERPINE1 (0.69) | SERPINE1IDO1PPARD | |
| SCHEMBL3959224 | 0.77 | SERPINE1 (0.53) | SERPINE1SCN9ACNR2 | |
| SCHEMBL4937574 | 0.77 | SERPINE1 (0.83) | SERPINE1IDO1PDE4APDE4BPDE4C | |
| SCHEMBL3867557 | 0.76 | SERPINE1 (0.55) | SERPINE1SCN9ACNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010171-A2 | INHIBITORS OF PAI-1 FOR TREATMENT OF MUSCULAR CONDITIONS | Wyeth a Corporation of the State of Delaware (US) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007098278-A2 | INHIBITORS OF PAI-1 FOR TREATMENT OF MUSCULAR CONDITIONS | WYETH (US) | 2007-08-30 | — | — | WO | disclosed |