SCHEMBL38662995

SCHEMBL38662995

COc1cc(C2CCN(C(=O)OC(C)(C)C)CC2)ccc1Nc1ncc(C(F)(F)F)c(C#Cc2ccccc2CC(N)=O)n1

nearest known ligand 0.61

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ PTK2 Q05397 14/20 0.61
▸ FLT4 P35916 10/20 0.61
▸ ALK Q9UM73 4/20 0.54
▸ EGFR P00533 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14648865 0.95 PTK2 (0.62) PTK2FLT4ALK
SCHEMBL14648859 0.94 ALK (0.55) PTK2FLT4ALKEGFR
SCHEMBL20725578 0.93 PTK2 (0.52) PTK2FLT4ALK
SCHEMBL14648389 0.88 PTK2 (0.51) PTK2FLT4ALKEGFR
SCHEMBL12479618 0.86 PTK2 (0.64) PTK2FLT4ALKEGFR
SCHEMBL12479555 0.86 PTK2 (0.82) PTK2FLT4ALK
SCHEMBL12479600 0.86 ALK (0.57) PTK2FLT4ALKEGFR
SCHEMBL38661017 0.86 PTK2 (0.71) PTK2FLT4ALK
SCHEMBL14635345 0.85 PTK2 (0.59) PTK2FLT4ALKEGFR
SCHEMBL15524190 0.84 PTK2 (0.53) PTK2FLT4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026097145-A1 FAK INHIBITORS AMPLIA THERAPEUTICS LIMITED (AU) 2026-05-15 — — WO disclosed
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