Narmafotinib

Narmafotinib

SCHEMBL38664161

[2H]C([2H])(c1ccccc1CC(N)=O)C([2H])([2H])c1nc(Nc2ccc(C3CCN(C)CC3)cc2OC)ncc1C(F)(F)F

nearest known ligand 0.85

Full drug profile on Sugi Atlas →

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ PTK2 Q05397 18/20 0.85
▸ FLT4 P35916 10/20 0.85
▸ EGFR P00533 1/20 0.56
▸ ALK Q9UM73 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Narmafotinib SCHEMBL38663363 0.96 PTK2 (0.79) PTK2FLT4ALK
Narmafotinib SCHEMBL12479576 0.92 PTK2 (1.00) PTK2FLT4
Narmafotinib SCHEMBL30354504 0.92 PTK2 (1.00) PTK2FLT4
SCHEMBL38661518 0.91 PTK2 (0.86) PTK2FLT4EGFR
SCHEMBL38661017 0.91 PTK2 (0.71) PTK2FLT4ALK
SCHEMBL38660963 0.88 PTK2 (0.80) PTK2FLT4EGFRALK
SCHEMBL14635846 0.86 PTK2 (1.00) PTK2FLT4
SCHEMBL12479598 0.85 PTK2 (0.87) PTK2FLT4ALK
SCHEMBL14635961 0.85 PTK2 (1.00) PTK2FLT4
SCHEMBL14635552 0.84 PTK2 (1.00) PTK2FLT4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026097145-A1 FAK INHIBITORS AMPLIA THERAPEUTICS LIMITED (AU) 2026-05-15 — — WO disclosed
Send feedback