Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 3/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.33 |
| ▸ | TTK | P33981 | 3/20 | 0.32 |
| ▸ | ATR | Q13535 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3855941 | 0.90 | FLT3 (0.37) | FLT3TGFBR1 | |
| SCHEMBL3844677 | 0.89 | FLT3 (0.37) | FLT3 | |
| SCHEMBL3866634 | 0.88 | FLT3 (0.38) | FLT3TGFBR1TTKATRADORA2A | |
| SCHEMBL3850042 | 0.86 | FLT3 (0.38) | FLT3 | |
| SCHEMBL3847153 | 0.81 | FLT3 (0.35) | FLT3 | |
| SCHEMBL3847887 | 0.75 | FLT3 (0.43) | FLT3TGFBR1 | |
| SCHEMBL3853073 | 0.75 | FLT3 (0.42) | FLT3TGFBR1 | |
| SCHEMBL3850996 | 0.75 | FLT3 (0.32) | FLT3 | |
| Hydrochloric Acid SCHEMBL3873523 | 0.75 | FLT3 (0.41) | FLT3TGFBR1TTKATRADORA2A | |
| SCHEMBL3845853 | 0.75 | FLT3 (0.36) | FLT3TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |