Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 19/20 | 0.58 |
| ▸ | BRAF | P15056 | 19/20 | 0.58 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3869116 | 0.93 | KIT (0.60) | KITBRAFFLT1KDR | |
| SCHEMBL3874895 | 0.88 | KIT (0.51) | KITBRAFFLT1KDR | |
| SCHEMBL3867387 | 0.82 | KIT (0.51) | KITBRAFFLT1KDR | |
| SCHEMBL3869758 | 0.78 | FLT1 (0.49) | KITBRAFFLT1KDR | |
| SCHEMBL3866458 | 0.78 | FLT1 (0.45) | KITBRAFFLT1KDR | |
| SCHEMBL3865807 | 0.76 | FLT1 (0.50) | KITBRAFFLT1KDR | |
| SCHEMBL1488724 | 0.75 | KIT (0.51) | KITBRAFFLT1KDR | |
| SCHEMBL3872732 | 0.74 | KIT (0.47) | KITBRAFFLT1KDR | |
| SCHEMBL1488398 | 0.74 | KIT (0.51) | KITBRAFFLT1KDR | |
| SCHEMBL1490859 | 0.74 | KIT (0.50) | KITBRAFFLT1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615565-B2 | VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridines | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-11-10 | — | — | US | disclosed |
| US-7517894-B2 | VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridines | BAYER SCHERING PHARMA AG (DE) | 2009-04-14 | — | — | US | disclosed |
| US-20070015794-A1 | Endothelial growth factor; angiogenesis inhibitors; antitumor agents; skin disorders; endimetriosis; Crohn's disease; leukemia; antiarthritic agents | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2007-01-18 | — | — | US | disclosed |
| US-7148357-B2 | VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridines | SCHERING AG (DE) | 2006-12-12 | — | — | US | disclosed |
| US-20050054654-A1 | VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridines | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2005-03-10 | — | — | US | disclosed |
| US-20040147535-A1 | VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridines | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2004-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070015794-A1 | Endothelial growth factor; angiogenesis inhibitors; antitumor agents; skin disorders; endimetriosis; Crohn's disease; leukemia; antiarthritic agents | FLT4, KDR, FLT1 | KIT 80/4885BRAF 34/4885FLT1 3/4885 |
| US-20040147535-A1 | VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridines | FLT4, KDR, FLT1 | KIT 28/4885BRAF 31/4885FLT1 3/4885 |
| US-20050054654-A1 | VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridines | FLT4, KDR, FLT1 | KIT 28/4885BRAF 31/4885FLT1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.