Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 12/20 | 0.72 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.71 |
| ▸ | HTR2A | P28223 | 3/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.71 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.66 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5912848 | 0.92 | MCHR1 (0.60) | MCHR1CHRM1HTR2ACYP2D6CHRM2 | |
| SCHEMBL3877227 | 0.87 | MCHR1 (0.79) | MCHR1CHRM1HTR2ACYP2D6KDM4E | |
| SCHEMBL3870965 | 0.86 | MCHR1 (0.75) | MCHR1CHRM1HTR2ACYP2D6CHRM2 | |
| SCHEMBL3876341 | 0.86 | KDM4E (0.76) | MCHR1CHRM1HTR2ACYP2D6KDM4E | |
| SCHEMBL3877390 | 0.84 | MCHR1 (1.00) | MCHR1CHRM1HTR2ACYP2D6CHRM4 | |
| SCHEMBL11758798 | 0.84 | TRPV1 (0.76) | TRPV1 | |
| SCHEMBL3868689 | 0.83 | MCHR1 (0.98) | MCHR1CHRM1HTR2ACYP2D6CHRM4 | |
| SCHEMBL3868266 | 0.83 | MCHR1 (0.82) | MCHR1CHRM1HTR2ACYP2D6CHRM4 | |
| SCHEMBL3879136 | 0.83 | MCHR1 (1.00) | MCHR1CHRM1HTR2ACYP2D6 | |
| SCHEMBL3875301 | 0.83 | MCHR1 (1.00) | MCHR1CHRM1HTR2ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7601868-B2 | Such as 4-(cyclopropylmethoxy)-N-(2-{4-[1-(1-pyrrolidinyl)ethyl]phenyl}ethyl)benzamide having melanin-concentrating hormone antagonistic action, for prophylaxis and/or treatment of obesity | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-10-13 | — | — | US | disclosed |
| US-7601868-B2 | Such as 4-(cyclopropylmethoxy)-N-(2-{4-[1-(1-pyrrolidinyl)ethyl]phenyl}ethyl)benzamide having melanin-concentrating hormone antagonistic action, for prophylaxis and/or treatment of obesity | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-10-13 | — | — | US | disclosed |
| US-7601868-B2 | Such as 4-(cyclopropylmethoxy)-N-(2-{4-[1-(1-pyrrolidinyl)ethyl]phenyl}ethyl)benzamide having melanin-concentrating hormone antagonistic action, for prophylaxis and/or treatment of obesity | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-10-13 | — | — | US | disclosed |