Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 11/20 | 0.51 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.51 |
| ▸ | EGFR | P00533 | 2/20 | 0.51 |
| ▸ | SMC2 | O95347 | 1/20 | 0.51 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.51 |
| ▸ | SMC1A | Q14683 | 1/20 | 0.51 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.51 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.51 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | NQO2 | P16083 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2021981 | 0.88 | MAP2K1 (0.47) | MAP2K1MAP2K2EGFRSMC2CSNK2A2 | |
| SCHEMBL1041456 | 0.87 | MAP2K1 (0.56) | MAP2K1MAP2K2EGFRSMC2CSNK2A2 | |
| SCHEMBL2023620 | 0.85 | MAP2K1 (0.57) | MAP2K1MAP2K2EGFRSMC2CSNK2A2 | |
| SCHEMBL4546113 | 0.85 | MAP2K1 (0.61) | MAP2K1MAP2K2EGFRSMC2CSNK2A2 | |
| SCHEMBL4546114 | 0.82 | MAP2K1 (0.78) | MAP2K1MAP2K2EGFRSMC2CSNK2A2 | |
| SCHEMBL1040484 | 0.81 | MAP2K1 (0.43) | MAP2K1MAP2K2EGFRSMC2CSNK2A2 | |
| SCHEMBL2280384 | 0.81 | MAP2K1 (0.45) | MAP2K1MAP2K2EGFRSMC2CSNK2A2 | |
| SCHEMBL1076098 | 0.79 | MAP2K1 (0.61) | MAP2K1MAP2K2EGFRSMC2CSNK2A2 | |
| SCHEMBL27601231 | 0.79 | MAP2K1 (0.52) | MAP2K1MAP2K2EGFRSMC2CSNK2A2 | |
| SCHEMBL27601233 | 0.79 | MAP2K1 (0.50) | MAP2K1MAP2K2EGFRSMC2CSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663210-A4 | N3 ALKYLATED BENZIMIDAZOLE DERIVATIVES AS MEK INHIBITORS | ARRAY BIOPHARMA INC (US) | 2009-04-22 | — | — | EP | disclosed |
| EP-1663210-A1 | N3 ALKYLATED BENZIMIDAZOLE DERIVATIVES AS MEK INHIBITORS | Array Biopharma, Inc. (US) | 2006-06-07 | — | — | EP | disclosed |
| EP-1482932-A4 | N3 ALKYLATED BENZIMIDAZOLE DERIVATIVES AS MEK INHIBITORS | ARRAY BIOPHARMA INC (US) | 2006-04-05 | — | — | EP | disclosed |
| WO-2005023251-A1 | N3 ALKYLATED BENZIMIDAZOLE DERIVATIVES AS MEK INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2005-03-17 | — | — | WO | disclosed |
| EP-1482932-A1 | N3 ALKYLATED BENZIMIDAZOLE DERIVATIVES AS MEK INHIBITORS | Array Biopharma, Inc. (US) | 2004-12-08 | — | — | EP | disclosed |
| WO-2003077914-A1 | N3 ALKYLATED BENZIMIDAZOLE DERIVATIVES AS MEK INHIBITORS | ARRAY BIOPHARMA, INC (US) | 2003-09-25 | — | — | WO | disclosed |