Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 19/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3864167 | 0.85 | MKNK1 (0.45) | MKNK1MKNK2PIK3CDPIK3R1 | |
| SCHEMBL3873946 | 0.83 | PIK3CD (0.51) | MKNK1PIK3CDPIK3R1 | |
| SCHEMBL3876102 | 0.80 | MKNK1 (0.41) | MKNK1MKNK2 | |
| SCHEMBL3867700 | 0.78 | MKNK1 (0.43) | MKNK1MKNK2 | |
| SCHEMBL3868130 | 0.76 | MKNK1 (0.46) | MKNK1MKNK2 | |
| SCHEMBL3867554 | 0.75 | MKNK1 (0.47) | MKNK1MKNK2PIK3CDPIK3R1 | |
| SCHEMBL3874890 | 0.74 | PIK3CD (0.47) | MKNK1PIK3CDPIK3R1 | |
| SCHEMBL16023579 | 0.74 | PIK3CD (0.55) | MKNK1MKNK2PIK3CDPIK3R1 | |
| SCHEMBL3867549 | 0.74 | MKNK1 (0.46) | MKNK1MKNK2PIK3CDPIK3R1 | |
| SCHEMBL3869837 | 0.73 | PIK3CD (0.45) | MKNK1PIK3CDPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8653076-B2 | Oxo-substituted imidazo[1,2B]pyridazines, their preparation and use as pharmaceuticals | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-02-18 | — | — | US | disclosed |
| US-20090093475-A1 | Oxo-substituted imidazo[1,2b]pyridazines, their preparation and use as pharmaceuticals | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2009-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090093475-A1 | Oxo-substituted imidazo[1,2b]pyridazines, their preparation and use as pharmaceuticals | CDK2, CDK1, MAP4K2 | MKNK1 299/4885MKNK2 203/4885PIK3CD 74/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.