Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.52 |
| ▸ | GRM5 | P41594 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | DPP4 | P27487 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL409828 | 0.89 | NPC1 (0.56) | KDM5AGRM5KMT2AALDH1A1MEN1 | |
| SCHEMBL27305516 | 0.76 | DPP4 (0.54) | KMT2ADPP4KCNH2DPP7POLB | |
| SCHEMBL412447 | 0.75 | NPC1 (0.62) | KDM5AGRM5KMT2ANPC1EPHX2 | |
| SCHEMBL3316788 | 0.75 | MEN1 (0.57) | KDM5AKMT2AALDH1A1HPGDMEN1 | |
| SCHEMBL3316785 | 0.75 | MEN1 (0.57) | KDM5AKMT2AALDH1A1HPGDMEN1 | |
| SCHEMBL3390856 | 0.75 | KMT2A (0.55) | KMT2AALDH1A1MEN1 | |
| SCHEMBL3390861 | 0.75 | KMT2A (0.55) | KMT2AALDH1A1MEN1 | |
| SCHEMBL3887575 | 0.74 | NPC1 (0.42) | KDM5AGRM5KMT2AMEN1NPC1 | |
| SCHEMBL29067099 | 0.74 | KMT2A (0.52) | KMT2A | |
| SCHEMBL29067104 | 0.74 | KMT2A (0.52) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2030970-A1 | Allosteric modulators of metabotropic glutamate receptors | ADDEX Pharma S.A. (CH) | 2009-03-04 | — | — | EP | claimed |
| EP-1685105-B1 | ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMA SA (CH) | 2008-10-15 | — | — | EP | claimed |