Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 5/20 | 0.34 |
| ▸ | TGFBR2 | P37173 | 3/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | AKT2 | P31751 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.32 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3872041 | 0.92 | MKNK1 (0.36) | FLT3POLBTGFBR1LCKAKT1 | |
| SCHEMBL3867609 | 0.89 | POLB (0.36) | POLBSCN9AEIF2AK4MKNK1MKNK2 | |
| SCHEMBL3877554 | 0.89 | MKNK1 (0.39) | FLT3POLBTGFBR1MKNK1MKNK2 | |
| SCHEMBL3873973 | 0.89 | GRM2 (0.32) | GRM2FLT3POLBTGFBR1TGFBR2 | |
| SCHEMBL4713756 | 0.85 | FLT3 (0.41) | FLT3TGFBR1AKT1AKT2MKNK1 | |
| Hydrochloric Acid SCHEMBL3864674 | 0.84 | FLT3 (0.38) | GRM2FLT3POLBTGFBR1TGFBR2 | |
| SCHEMBL3872044 | 0.81 | MKNK1 (0.32) | POLBAKT1AKT2MKNK1MKNK2 | |
| SCHEMBL3846603 | 0.81 | FLT3 (0.41) | FLT3TGFBR1TGFBR2 | |
| SCHEMBL3867613 | 0.78 | POLB (0.32) | POLBSCN9AEIF2AK4 | |
| SCHEMBL3877558 | 0.78 | MKNK1 (0.34) | POLBMKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048142-A2 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2009-04-15 | — | — | EP | disclosed |
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |
| US-7074801-B1 | Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof | EISAI CO., LTD. (JP) | 2006-07-11 | — | — | US | disclosed |
| EP-1382603-A1 | NITROGENOUS FUSED−RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-01-21 | — | — | EP | disclosed |