Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.70 |
| ▸ | TSHR | P16473 | 8/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.68 |
| ▸ | HTT | P42858 | 6/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.68 |
| ▸ | MEN1 | O00255 | 4/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.68 |
| ▸ | HPGD | P15428 | 3/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.68 |
| ▸ | TP53 | P04637 | 2/20 | 0.68 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.68 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 7/20 | 0.67 |
| ▸ | HRH1 | P35367 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | KIT | P10721 | 3/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3876311 | 0.84 | MAPT (0.73) | MAPTALDH1A1TSHRHSD17B10HTT | |
| SCHEMBL13771254 | 0.83 | MAPT (0.68) | MAPTALDH1A1TSHRHSD17B10HTT | |
| SCHEMBL606545 | 0.81 | HRH4 (1.00) | MAPTALDH1A1TSHRHSD17B10HTT | |
| SCHEMBL615146 | 0.79 | MAPT (0.72) | MAPTALDH1A1TSHRHSD17B10HTT | |
| SCHEMBL13771714 | 0.76 | KIT (0.70) | MAPTALDH1A1TSHRHSD17B10HTT | |
| SCHEMBL15384142 | 0.75 | KIT (0.72) | MAPTALDH1A1TSHRHSD17B10HTT | |
| SCHEMBL22191495 | 0.74 | NPSR1 (0.74) | MAPTALDH1A1TSHRHSD17B10HTT | |
| SCHEMBL29436132 | 0.74 | NPSR1 (0.74) | MAPTALDH1A1TSHRHSD17B10HTT | |
| SCHEMBL13771287 | 0.73 | KIT (0.77) | MAPTALDH1A1TSHRHSD17B10HTT | |
| SCHEMBL22191538 | 0.71 | HSD17B10 (1.00) | MAPTALDH1A1TSHRHSD17B10HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8999988-B2 | Protein kinase inhibitors | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2015-04-07 | — | — | US | disclosed |
| US-20130302303-A1 | PROTEIN KINASE INHIBITORS | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA | 2013-11-14 | — | — | US | disclosed |
| US-8552018-B2 | Substituted tricyclic compounds as protein kinase inhibitors | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2013-10-08 | — | — | US | disclosed |
| EP-1678166-B1 | PROTEIN KINASE INHIBITORS | UNIV ARIZONA (US) | 2009-07-29 | — | — | EP | disclosed |
| US-20090143399-A1 | Protein Kinase Inhibitors | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2009-06-04 | — | — | US | disclosed |
| US-20090099165-A1 | Protein Kinase Inhibitors | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2009-04-16 | — | — | US | disclosed |
| US-20080051414-A1 | Protein Kinase Inhibitors | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2008-02-28 | — | — | US | disclosed |
| US-7335662-B2 | Substituted tricyclic compounds as protein kinase inhibitors | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2008-02-26 | — | — | US | disclosed |
| US-7326712-B2 | Substituted tricyclic compounds as protein kinase inhibitors | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2008-02-05 | — | — | US | disclosed |
| US-7326713-B2 | Substituted tricyclic compound as protein kinase inhibitors | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2008-02-05 | — | — | US | disclosed |
| US-7312226-B2 | Substituted tricyclic compounds as protein kinase inhibitors | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2007-12-25 | — | — | US | disclosed |
| US-20050277658-A1 | Protein kinase inhibitors | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2005-12-15 | — | — | US | disclosed |
| US-20050239793-A1 | Protein kinase inhibitors | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2005-10-27 | — | — | US | disclosed |
| US-20050239794-A1 | Protein kinase inhibitors | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2005-10-27 | — | — | US | disclosed |
| US-20050227992-A1 | Protein kinase inhibitors | ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2005-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099165-A1 | Protein Kinase Inhibitors | CDK2, MAP3K1, MAP3K2 | MAPT 4041/4885ALDH1A1 2994/4885TSHR 2097/4885 |
| US-20050227992-A1 | Protein kinase inhibitors | CDK2, MAP3K1, MAP3K2 | MAPT 4041/4885ALDH1A1 2994/4885TSHR 2097/4885 |
| US-20050277658-A1 | Protein kinase inhibitors | CDK2, MAP3K1, MAP3K2 | MAPT 4041/4885ALDH1A1 2994/4885TSHR 2097/4885 |
| US-20050239794-A1 | Protein kinase inhibitors | CDK2, MAP3K1, MAP3K2 | MAPT 4041/4885ALDH1A1 2994/4885TSHR 2097/4885 |
| US-20050239793-A1 | Protein kinase inhibitors | CDK2, MAP3K1, MAP3K2 | MAPT 4041/4885ALDH1A1 2994/4885TSHR 2097/4885 |
| US-20130302303-A1 | PROTEIN KINASE INHIBITORS | CDK2, MAP3K1, MAP3K2 | MAPT 4041/4885ALDH1A1 2994/4885TSHR 2097/4885 |
| US-20080051414-A1 | Protein Kinase Inhibitors | CDK2, MAP3K1, MAP3K2 | MAPT 4041/4885ALDH1A1 2994/4885TSHR 2097/4885 |
| US-20090143399-A1 | Protein Kinase Inhibitors | CDK2, MAP3K1, MAP3K2 | MAPT 4041/4885ALDH1A1 2994/4885TSHR 2097/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.