Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 19/20 | 0.56 |
| ▸ | RAF1 | P04049 | 16/20 | 0.56 |
| ▸ | KDR | P35968 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2676252 | 0.92 | BRAF (0.60) | BRAFRAF1KDR | |
| SCHEMBL3879459 | 0.86 | BRAF (0.60) | BRAFRAF1KDR | |
| SCHEMBL2675928 | 0.85 | BRAF (0.61) | BRAFRAF1KDR | |
| SCHEMBL3882733 | 0.84 | BRAF (0.55) | BRAFRAF1KDR | |
| SCHEMBL27738988 | 0.84 | BRAF (0.62) | BRAFRAF1KDR | |
| SCHEMBL3877357 | 0.83 | BRAF (0.51) | BRAFRAF1KDR | |
| SCHEMBL2675995 | 0.82 | BRAF (0.60) | BRAFRAF1KDR | |
| SCHEMBL2676429 | 0.81 | RAF1 (0.65) | BRAFRAF1KDR | |
| SCHEMBL2678171 | 0.81 | BRAF (0.58) | BRAFRAF1KDR | |
| SCHEMBL2676633 | 0.81 | RAF1 (0.57) | BRAFRAF1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010528-A2 | 6-O-SUBSTITUTED BENZOXAZOLE AND BENZOTHIAZOLE COMPOUNDS AND METHODS OF INHIBITING CSF-1R SIGNALING | Novartis Pharma AG (CH) | 2009-01-07 | — | — | EP | claimed |
| WO-2007121484-A2 | 6-O-SUBSTITUTED BENZOXAZOLE AND BENZOTHIAZOLE COMPOUNDS AND METHODS OF INHIBITING CSF-1R SIGNALING | NOVARTIS AG (CH) | 2007-10-25 | — | — | WO | claimed |