Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GALR2 | O43603 | 4/20 | 0.48 |
| ▸ | GALR1 | P47211 | 4/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.39 |
| ▸ | PHGDH | O43175 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3878916 | 0.91 | GALR2 (0.46) | GALR2GALR1EPHX2HSD11B1 | |
| SCHEMBL3884237 | 0.88 | GALR2 (0.46) | GALR2GALR1EPHX2HSD11B1 | |
| SCHEMBL3878072 | 0.88 | GALR2 (0.59) | GALR2GALR1 | |
| SCHEMBL3877905 | 0.87 | GALR2 (0.48) | GALR2GALR1EPHX2HSD11B1PHGDH | |
| SCHEMBL3888381 | 0.87 | GALR2 (0.61) | GALR2GALR1 | |
| SCHEMBL3889943 | 0.86 | TRPV1 (0.48) | GALR2GALR1 | |
| SCHEMBL3878216 | 0.86 | TRPV1 (0.48) | GALR2GALR1 | |
| SCHEMBL3885552 | 0.85 | GALR2 (0.47) | GALR2GALR1EPHX2HSD11B1PHGDH | |
| SCHEMBL3877850 | 0.85 | EPHX2 (0.54) | GALR2GALR1EPHX2 | |
| SCHEMBL13761377 | 0.85 | GALR2 (0.51) | GALR2GALR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |