Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 5/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | MAP3K12 | Q12852 | 4/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | KHK | P50053 | 2/20 | 0.36 |
| ▸ | GALR2 | O43603 | 1/20 | 0.36 |
| ▸ | GALR1 | P47211 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3878207 | 0.94 | GRM5 (0.41) | GRM5TRPV1DYRK1AMAP3K12PDE4A | |
| SCHEMBL3880930 | 0.94 | TRPV1 (0.38) | GRM5TRPV1DYRK1AMAP3K12KHK | |
| SCHEMBL14613908 | 0.93 | MAP3K12 (0.39) | GRM5TRPV1DYRK1AMAP3K12KHK | |
| SCHEMBL3879062 | 0.92 | TRPV1 (0.43) | GRM5TRPV1DYRK1A | |
| SCHEMBL3875754 | 0.92 | TRPV1 (0.37) | TRPV1DYRK1AMAP3K12KHK | |
| SCHEMBL3879480 | 0.91 | SYK (0.42) | TRPV1DYRK1AMAP3K12KHKKDM4E | |
| SCHEMBL3889943 | 0.91 | TRPV1 (0.48) | TRPV1MAP3K12KHKGALR2GALR1 | |
| SCHEMBL3877121 | 0.90 | TRPV1 (0.42) | GRM5TRPV1 | |
| SCHEMBL3878216 | 0.88 | TRPV1 (0.48) | GRM5TRPV1KHKGALR2GALR1 | |
| SCHEMBL3877937 | 0.87 | DYRK1A (0.38) | TRPV1DYRK1AMAP3K12KHKGALR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |