Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 7/20 | 0.48 |
| ▸ | MAOA | P21397 | 3/20 | 0.48 |
| ▸ | CNR2 | P34972 | 4/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | CA5A | P35218 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4042357 | 0.87 | CNR2 (0.54) | TP53MAPTMAOBMAOACNR2 | |
| SCHEMBL4522651 | 0.87 | MAOB (0.59) | TP53MAPTMAOBMAOACNR2 | |
| SCHEMBL3882211 | 0.87 | CNR2 (0.52) | TP53MAPTMAOBMAOACNR2 | |
| SCHEMBL4522656 | 0.86 | TP53 (0.50) | TP53MAPTMAOBMAOACNR2 | |
| SCHEMBL3882544 | 0.84 | S1PR1 (0.54) | TP53MAPTMAOBMAOACNR2 | |
| SCHEMBL3883450 | 0.84 | S1PR1 (0.52) | TP53MAPTMAOBMAOACNR2 | |
| SCHEMBL3883904 | 0.84 | CNR2 (0.58) | TP53MAPTMAOBMAOACNR2 | |
| SCHEMBL4518185 | 0.84 | TP53 (0.48) | TP53MAPTMAOBMAOACNR2 | |
| SCHEMBL3880309 | 0.83 | TP53 (0.56) | TP53MAPTMAOBMAOACNR2 | |
| SCHEMBL4532090 | 0.83 | CNR2 (0.59) | TP53MAPTMAOBMAOACNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010511-A1 | CHROMEN-2-ONE DERIVATIVES | Novartis AG (CH) | 2009-01-07 | — | — | EP | claimed |
| WO-2007115820-A1 | CHROMEN-2-ONE DERIVATIVES | NOVARTIS AG (CH) | 2007-10-18 | — | — | WO | claimed |