Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.47 |
| ▸ | GALR2 | O43603 | 4/20 | 0.42 |
| ▸ | GALR1 | P47211 | 4/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.40 |
| ▸ | KHK | P50053 | 2/20 | 0.38 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3878236 | 0.86 | TRPV1 (0.49) | TRPV1GALR2GALR1HSD11B1KHK | |
| SCHEMBL3888879 | 0.86 | TRPV1 (0.49) | TRPV1GALR2GALR1KHKMAP3K12 | |
| SCHEMBL3879868 | 0.85 | TRPV1 (0.50) | TRPV1GALR2GALR1HSD11B1KHK | |
| SCHEMBL3889943 | 0.84 | TRPV1 (0.48) | TRPV1GALR2GALR1KHKMAP3K12 | |
| SCHEMBL3879931 | 0.84 | PIK3R1 (0.46) | TRPV1GALR2GALR1MAP3K12 | |
| SCHEMBL3879378 | 0.84 | TRPV1 (0.47) | TRPV1GALR2GALR1HSD11B1 | |
| SCHEMBL3878216 | 0.82 | TRPV1 (0.48) | TRPV1GALR2GALR1KHK | |
| SCHEMBL3876175 | 0.81 | TRPV1 (0.48) | TRPV1GALR2GALR1HSD11B1KHK | |
| SCHEMBL3884821 | 0.81 | TRPV1 (0.53) | TRPV1GALR2GALR1HSD11B1 | |
| SCHEMBL3877016 | 0.80 | TRPV1 (0.44) | TRPV1GALR2GALR1KHKMAP3K12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |