Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 12/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | MAP3K12 | Q12852 | 3/20 | 0.36 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3880768 | 1.00 | TRPV1 (0.49) | TRPV1KDM4ENPC1TSHRRAB9A | |
| SCHEMBL3883796 | 1.00 | TRPV1 (0.49) | TRPV1KDM4ENPC1TSHRRAB9A | |
| SCHEMBL3941468 | 0.94 | TRPV1 (0.51) | TRPV1MAP3K12MALT1HSD11B1CHRM4 | |
| SCHEMBL3878083 | 0.93 | TRPV1 (0.49) | TRPV1MAP3K12MALT1HSD11B1CHRM4 | |
| SCHEMBL3879735 | 0.93 | TRPV1 (0.49) | TRPV1MAP3K12MALT1HSD11B1CHRM4 | |
| SCHEMBL13761545 | 0.93 | TRPV1 (0.49) | TRPV1MAP3K12MALT1HSD11B1CHRM4 | |
| SCHEMBL13761558 | 0.93 | TRPV1 (0.49) | TRPV1MAP3K12MALT1HSD11B1CHRM4 | |
| SCHEMBL3888352 | 0.93 | TRPV1 (0.49) | TRPV1MAP3K12MALT1HSD11B1CHRM4 | |
| SCHEMBL3883269 | 0.93 | TRPV1 (0.49) | TRPV1MAP3K12MALT1HSD11B1CHRM4 | |
| SCHEMBL3885655 | 0.93 | TRPV1 (0.46) | TRPV1MAP3K12HSD11B1CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |