Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 11/20 | 0.60 |
| ▸ | MAP3K7 | O43318 | 10/20 | 0.60 |
| ▸ | MAP4K2 | Q12851 | 10/20 | 0.60 |
| ▸ | KDR | P35968 | 3/20 | 0.59 |
| ▸ | BRAF | P15056 | 2/20 | 0.59 |
| ▸ | TNNI3K | Q59H18 | 2/20 | 0.59 |
| ▸ | MAP3K20 | Q9NYL2 | 8/20 | 0.49 |
| ▸ | FES | P07332 | 4/20 | 0.49 |
| ▸ | FER | P16591 | 4/20 | 0.49 |
| ▸ | EPHA2 | P29317 | 4/20 | 0.49 |
| ▸ | CSK | P41240 | 4/20 | 0.49 |
| ▸ | ABL1 | P00519 | 4/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.49 |
| ▸ | FLT3 | P36888 | 3/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.49 |
| ▸ | RAF1 | P04049 | 3/20 | 0.49 |
| ▸ | LYN | P07948 | 3/20 | 0.49 |
| ▸ | SRC | P12931 | 3/20 | 0.49 |
| ▸ | EPHB2 | P29323 | 3/20 | 0.49 |
| ▸ | ABL2 | P42684 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3880675 | 0.91 | MAPK14 (0.71) | MAPK14MAP3K7MAP4K2KDRBRAF | |
| SCHEMBL2848857 | 0.85 | MAPK14 (0.73) | MAPK14MAP3K7MAP4K2KDRBRAF | |
| SCHEMBL4791338 | 0.82 | MAP3K7 (0.62) | MAPK14MAP3K7MAP4K2KDRBRAF | |
| SCHEMBL14690370 | 0.77 | MAP3K7 (0.85) | MAPK14MAP3K7MAP4K2KDRBRAF | |
| SCHEMBL30692256 | 0.77 | MAP3K7 (0.85) | MAPK14MAP3K7MAP4K2KDRBRAF | |
| SCHEMBL12999177 | 0.76 | MAPK14 (0.58) | MAPK14MAP3K7MAP4K2KDRBRAF | |
| SCHEMBL2848934 | 0.76 | KDR (1.00) | MAPK14KDRBRAFTNNI3KFLT3 | |
| SCHEMBL23353598 | 0.76 | MAP3K7 (0.66) | MAPK14MAP3K7MAP4K2KDRBRAF | |
| SCHEMBL30692261 | 0.75 | MAP3K7 (1.00) | MAPK14MAP3K7MAP4K2MAP3K20FES | |
| SCHEMBL14690002 | 0.75 | MAP3K7 (1.00) | MAPK14MAP3K7MAP4K2MAP3K20FES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940844-B1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-09-30 | — | — | EP | claimed |