Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | PLEC | Q15149 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 10/20 | 0.47 |
| ▸ | MAOA | P21397 | 3/20 | 0.47 |
| ▸ | F12 | P00748 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
| ▸ | CA5A | P35218 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4523523 | 0.83 | MAPT (0.53) | MAPTPOLBMEN1KMT2APLEC | |
| SCHEMBL3880564 | 0.80 | MAPT (0.77) | MAPTPOLBMEN1KMT2APLEC | |
| SCHEMBL4531436 | 0.77 | MAPT (0.55) | MAPTPOLBMEN1KMT2APLEC | |
| SCHEMBL28641067 | 0.77 | MAPT (0.76) | MAPTPOLBMEN1KMT2ANPC1 | |
| SCHEMBL3878896 | 0.76 | MAPT (0.54) | MAPTPOLBMEN1KMT2APLEC | |
| SCHEMBL3955610 | 0.75 | TP53 (0.55) | MAPTTP53MAOBMAOA | |
| SCHEMBL4520996 | 0.75 | TP53 (0.56) | MAPTTP53MAOBMAOA | |
| SCHEMBL3952993 | 0.74 | TP53 (0.55) | MAPTTP53MAOBMAOAKDM4E | |
| SCHEMBL4528661 | 0.73 | MAPT (0.42) | MAPTPOLBMEN1KMT2APLEC | |
| SCHEMBL3880339 | 0.73 | S1PR1 (0.63) | MAPTPOLBLMNATP53MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010511-A1 | CHROMEN-2-ONE DERIVATIVES | Novartis AG (CH) | 2009-01-07 | — | — | EP | claimed |
| WO-2007115820-A1 | CHROMEN-2-ONE DERIVATIVES | NOVARTIS AG (CH) | 2007-10-18 | — | — | WO | claimed |