Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 5/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 6/20 | 0.48 |
| ▸ | MAOA | P21397 | 4/20 | 0.48 |
| ▸ | CNR2 | P34972 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | CA5A | P35218 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3955101 | 1.00 | S1PR1 (0.60) | S1PR1TP53MAPTMAOBMAOA | |
| SCHEMBL3955097 | 1.00 | S1PR1 (0.60) | S1PR1TP53MAPTMAOBMAOA | |
| SCHEMBL3885592 | 0.93 | TP53 (0.54) | S1PR1TP53MAPTMAOBMAOA | |
| SCHEMBL3880851 | 0.92 | S1PR1 (0.61) | S1PR1TP53MAPTMAOBMAOA | |
| SCHEMBL3880374 | 0.90 | S1PR1 (0.60) | S1PR1TP53MAPTMAOBMAOA | |
| SCHEMBL4515744 | 0.90 | S1PR1 (0.62) | S1PR1TP53MAPTMAOBMAOA | |
| SCHEMBL3880282 | 0.90 | S1PR1 (0.62) | S1PR1TP53MAPTMAOBMAOA | |
| SCHEMBL1654629 | 0.89 | S1PR1 (0.66) | S1PR1TP53MAPTMAOBMAOA | |
| SCHEMBL3888192 | 0.88 | S1PR1 (0.58) | S1PR1TP53MAPTMAOBMAOA | |
| SCHEMBL3880659 | 0.88 | S1PR1 (0.65) | S1PR1TP53MAPTMAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010511-A1 | CHROMEN-2-ONE DERIVATIVES | Novartis AG (CH) | 2009-01-07 | — | — | EP | claimed |
| WO-2007115820-A1 | CHROMEN-2-ONE DERIVATIVES | NOVARTIS AG (CH) | 2007-10-18 | — | — | WO | claimed |