⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28556249 | 0.94 | TSHR (0.33) | — | |
| SCHEMBL1002901 | 0.79 | TSHR (0.41) | — | |
| SCHEMBL18132831 | 0.78 | TSHR (0.31) | — | |
| SCHEMBL12339113 | 0.78 | TSHR (0.32) | — | |
| SCHEMBL1114619 | 0.77 | — | — | |
| SCHEMBL165457 | 0.75 | — | — | |
| SCHEMBL7280456 | 0.75 | — | — | |
| SCHEMBL8067739 | 0.75 | TSHR (0.36) | — | |
| SCHEMBL28117052 | 0.75 | — | — | |
| SCHEMBL429953 | 0.73 | FFAR3 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 946 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4733307-A1 | METHOD FOR PRODUCING PEPTIDE COMPOUND USING MIXED ANHYDRIDE PROCEDURE | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2026-04-29 | — | — | EP | claimed |
| WO-2025070753-A1 | METHOD FOR PRODUCING PEPTIDE COMPOUND USING MIXED ANHYDRIDE PROCEDURE | 中外製薬株式会社 | 2025-04-03 | — | — | WO | claimed |
| CN-118598745-A | Synthesis method of 2, 2-dimethylbutyryl chloride | 江苏阿尔法药业股份有限公司 | 2024-09-06 | — | — | CN | claimed |
| CN-116715573-A | Synthesis method of 2, 2-dimethylbutyryl chloride | 河北华旭化工有限公司 | 2023-09-08 | — | — | CN | claimed |
| CN-114369082-B | Pyridine substituted spiro compounds and application thereof in preparation of anti-plant virus agent | 贵州大学 | 2023-09-05 | — | — | CN | claimed |
| CN-114349726-B | 2,2' -difluoro-4, 4', 5' -biphenyl tetracarboxylic dianhydride monomer, and preparation method and application thereof | 华南理工大学 | 2023-05-23 | — | — | CN | claimed |
| WO-2022149612-A1 | METHOD FOR PRODUCING PEPTIDE | 日産化学株式会社 | 2022-07-14 | — | — | WO | claimed |
| CN-114349726-A | 2,2 ' -difluoro-4, 4 ', 5,5 ' -biphenyl tetracarboxylic dianhydride monomer and preparation method and application thereof | 华南理工大学 | 2022-04-15 | — | — | CN | claimed |
| CN-108779140-B | Compounds and methods for synthesizing 5- (N-protected tryptophanyl carboxamide) -2' -deoxyuridine phosphoramidites for incorporation into nucleic acid sequences | 私募蛋白质体操作有限公司 | 2022-04-12 | — | — | CN | claimed |
| EP-3847155-A1 | A METHOD FOR THE PREPARATION OF FLUOROALKYL NITRILES AND THEIR USE TO PREPARE RELATED FLUOROALKYL TETRAZOLES | PI Industries Ltd. (IN) | 2021-07-14 | — | — | EP | claimed |
| EP-1463723-A1 | PROCESS FOR THE PREPARATION OF SIMVASTATIN | Hanmi Pharm. Co., Ltd. (KR) | 2004-10-06 | — | — | EP | claimed |
| WO-2003057684-A1 | PROCESS FOR THE PREPARATION OF SIMVASTATIN | HANMI PHARM. CO., LTD. (KR) | 2003-07-17 | — | — | WO | claimed |
| US-6331641-B1 | Process for producing simvastatin | KANEKA CORPORATION (JP) | 2001-12-18 | — | — | US | claimed |
| EP-1055671-A1 | PROCESS FOR PRODUCING SIMVASTATIN | KANEKA CORPORATION (JP) | 2000-11-29 | — | — | EP | claimed |
| EP-0511867-B1 | Process for the preparation of simvastatin | MERCK & CO INC (US) | 1996-08-21 | — | — | EP | claimed |
| EP-0511867-A1 | Process for the preparation of simvastatin | MERCK & CO. INC. (US) | 1992-11-04 | — | — | EP | claimed |
| US-5159104-A | Reacting 4-acyl simvastatin with aliphatic alcohol and acid | MERCK & CO., INC. (US) | 1992-10-27 | — | — | US | claimed |
| US-5099035-A | Lactonization, reacting the triol with a silyl chloride protecting group | E. R. SQUIBB & SONS, INC. (US) | 1992-03-24 | — | — | US | claimed |
| EP-0094443-A1 | 6(R)-(2-(8(S) (2,2-dimethylbutyryloxy)-2(S),6(S)-dimethyl-1,2,3,4,4a(S),5,6,7,8,8a(S)-decahydronaphthyl-1(S))ethyl)-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one, process for preparing and pharmaceutical composition containing the same | MERCK & CO. INC. (US) | 1983-11-23 | — | — | EP | claimed |
| US-4123447-A | REACTING (1,5-CYCLOOCTADIENE)BIS(TRIETHYLPHOSPHINE)-NICKEL(O) WITH AN ACYL HALIDE, OLIGOMERIZATION CATALYSTS | PHILLIPS PETROLEUM COMPANY (US) | 1978-10-31 | — | — | US | claimed |