Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | GPR88 | Q9GZN0 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3889429 | 0.95 | EGFR (0.34) | EGFRFGFR2IRAK4JAK3GPR88 | |
| SCHEMBL3996368 | 0.94 | EGFR (0.35) | EGFRFGFR2IRAK4JAK3GPR88 | |
| SCHEMBL3883320 | 0.89 | IRAK4 (0.37) | EGFRFGFR2IRAK4JAK3MAPK1 | |
| SCHEMBL3886266 | 0.88 | IRAK4 (0.37) | EGFRFGFR2IRAK4JAK3MAPK1 | |
| SCHEMBL3881367 | 0.88 | IRAK4 (0.43) | EGFRFGFR2IRAK4JAK3MAP4K1 | |
| SCHEMBL3881918 | 0.84 | CASR (0.38) | EGFRIRAK4JAK3MAPK1ROCK2 | |
| SCHEMBL3880451 | 0.81 | EGFR (0.39) | EGFRROCK2ROCK1 | |
| SCHEMBL3883288 | 0.80 | EGFR (0.34) | EGFRIRAK4MAP4K1ROCK2ROCK1 | |
| SCHEMBL3892410 | 0.77 | IRAK4 (0.43) | EGFRIRAK4JAK3ROCK2ROCK1 | |
| SCHEMBL3882523 | 0.77 | EGFR (0.39) | EGFRROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1771443-B1 | QUINOLINE THIAZOLINONES WITH CDK-1 ANTIPROLIFERATIVE ACTIVITY | HOFFMANN LA ROCHE (CH) | 2009-01-07 | — | — | EP | claimed |