Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 14/20 | 0.53 |
| ▸ | BRAF | P15056 | 14/20 | 0.53 |
| ▸ | KDR | P35968 | 3/20 | 0.49 |
| ▸ | CSF1R | P07333 | 4/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | KIT | P10721 | 1/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3884227 | 1.00 | RAF1 (0.53) | RAF1BRAFKDRCSF1RPDGFRB | |
| SCHEMBL2677337 | 0.87 | RAF1 (0.66) | RAF1BRAFKDRCSF1RPDGFRB | |
| SCHEMBL2675940 | 0.87 | RAF1 (0.66) | RAF1BRAFKDRCSF1RPDGFRB | |
| SCHEMBL27759776 | 0.87 | RAF1 (0.51) | RAF1BRAFKDRCSF1RPDGFRB | |
| SCHEMBL2677551 | 0.87 | RAF1 (0.51) | RAF1BRAFKDRCSF1RPDGFRB | |
| SCHEMBL2677540 | 0.87 | RAF1 (0.51) | RAF1BRAFKDRCSF1RPDGFRB | |
| SCHEMBL2675995 | 0.86 | BRAF (0.60) | RAF1BRAFKDR | |
| SCHEMBL2678566 | 0.85 | RAF1 (0.54) | RAF1BRAFKDRCSF1RPDGFRB | |
| SCHEMBL2677410 | 0.85 | RAF1 (0.54) | RAF1BRAFKDRCSF1RPDGFRB | |
| SCHEMBL2677414 | 0.85 | RAF1 (0.54) | RAF1BRAFKDRCSF1RPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010528-A2 | 6-O-SUBSTITUTED BENZOXAZOLE AND BENZOTHIAZOLE COMPOUNDS AND METHODS OF INHIBITING CSF-1R SIGNALING | Novartis Pharma AG (CH) | 2009-01-07 | — | — | EP | claimed |
| WO-2007121484-A2 | 6-O-SUBSTITUTED BENZOXAZOLE AND BENZOTHIAZOLE COMPOUNDS AND METHODS OF INHIBITING CSF-1R SIGNALING | NOVARTIS AG (CH) | 2007-10-25 | — | — | WO | claimed |